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Jordan A Kreidberg

Explore the profile of Jordan A Kreidberg including associated specialties, affiliations and a list of published articles. Areas
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Articles 51
Citations 2191
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Recent Articles
1.
Taglienti M, Graf D, Schumacher V, Kreidberg J
Development . 2022 Jul; 149(14). PMID: 35877077
The mammalian kidney is composed of thousands of nephrons that are formed through reiterative induction of a mesenchymal-to-epithelial transformation by a population of nephron progenitor cells. The number of nephrons...
2.
Kreidberg J, Schumacher V
J Clin Invest . 2022 Feb; 132(4). PMID: 35166232
Kidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3β (GSK3β) is...
3.
Ettou S, Jung Y, Miyoshi T, Jain D, Hiratsuka K, Schumacher V, et al.
Sci Adv . 2020 Aug; 6(30):eabb5460. PMID: 32754639
In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in reparative responses to injury are not well understood. We have studied the mechanisms of transcriptional...
4.
Zhang L, Ettou S, Khalid M, Taglienti M, Jain D, Jung Y, et al.
Development . 2018 Jun; 145(14). PMID: 29945864
Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem and progenitor populations during organogenesis. The mammalian kidney maintains a population of self-renewing...
5.
Puri P, Schaefer C, Bushnell D, Taglienti M, Kreidberg J, Yoder B, et al.
Am J Pathol . 2017 Nov; 188(1):84-94. PMID: 29107072
Ectopic cAMP signaling is pathologic in polycystic kidney disease; however, its spatiotemporal actions are unclear. We characterized the expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling,...
6.
Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al.
Development . 2015 Mar; 142(7):1254-66. PMID: 25804736
Development of the metanephric kidney depends on tightly regulated interplay between self-renewal and differentiation of a nephron progenitor cell (NPC) pool. Several key factors required for the survival of NPCs...
7.
Kann M, Ettou S, Jung Y, Lenz M, Taglienti M, Park P, et al.
J Am Soc Nephrol . 2015 Feb; 26(9):2097-104. PMID: 25636411
The transcription factor Wilms' tumor suppressor 1 (WT1) is key to podocyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive. We provide a comprehensive analysis of the...
8.
Zhang A, Wu S, Jung Y, Qin S, Hancock W, Kreidberg J
J Proteome Res . 2014 Oct; 13(11):4901-9. PMID: 25300029
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder caused by mutations in the Pkd1 or Pkd2 genes, in which large cysts replace normal kidney tissue, leading to...
9.
Chu J, Sims-Lucas S, Bushnell D, Bodnar A, Kreidberg J, Ho J
Am J Physiol Renal Physiol . 2014 Feb; 306(7):F764-72. PMID: 24500693
MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3'-untranslated region (3'-UTR) of target genes. They require processing by Dicer, an RNase III...
10.
McMahon G, Datta D, Bruneau S, Kann M, Khalid M, Ho J, et al.
Biochem Biophys Res Commun . 2012 Jul; 425(2):244-9. PMID: 22828505
Agents that target the activity of the mammalian target of rapamycin (mTOR) kinase in humans are associated with proteinuria. However, the mechanisms underlying mTOR activity and signaling within the kidney...