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Joost Haasnoot

Explore the profile of Joost Haasnoot including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 831
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Recent Articles
1.
Schopman N, van Montfort T, Willemsen M, Knoepfel S, Pollakis G, van Kampen A, et al.
Virus Res . 2012 Jun; 169(2):438-47. PMID: 22728443
Retroviral particles are known to package specific host cell components such as RNA molecules in addition to the two copies of the viral RNA genome. The highly sensitive SOLiD sequencing...
2.
Schopman N, Willemsen M, Liu Y, Bradley T, van Kampen A, Baas F, et al.
Nucleic Acids Res . 2011 Sep; 40(1):414-27. PMID: 21911362
Small virus-derived interfering RNAs (viRNAs) play an important role in antiviral defence in plants, insects and nematodes by triggering the RNA interference (RNAi) pathway. The role of RNAi as an...
3.
Haasnoot J, Berkhout B
Methods Mol Biol . 2011 Mar; 721:23-41. PMID: 21431677
MicroRNAs (miRNAs) play an essential role in the regulation of eukaryotic gene expression. Recent studies demonstrate that miRNAs can also strongly affect the replication of pathogenic viruses. For example, cellular...
4.
Schopman N, Heynen S, Haasnoot J, Berkhout B
RNA Biol . 2010 Sep; 7(5):573-6. PMID: 20818168
The rapid release of new data from DNA genome sequencing projects has led to a variety of misannotations in public databases. Our results suggest that next generation sequencing approaches are...
5.
Liu Y, Jasmijn von Eije K, Schopman N, Westerink J, Brake O, Haasnoot J, et al.
Mol Ther . 2009 Aug; 17(10):1712-23. PMID: 19672247
RNA interference (RNAi) is a widely used gene suppression tool that holds great promise as a novel antiviral approach. However, for error-prone viruses including human immunodeficiency virus type 1(HIV-1), a...
6.
Liu Y, Gruber J, Haasnoot J, Konstantinova P, Berkhout B
Nucleic Acids Res . 2009 Aug; 37(18):6194-204. PMID: 19656954
Potent antiviral RNAi can be induced by intracellular expression of short hairpin RNAs (shRNAs) and artificial microRNAs (miRNAs). Expression of shRNA and miRNA results in target mRNA degradation (perfect base...
7.
de Vries W, Haasnoot J, Fouchier R, de Haan P, Berkhout B
J Gen Virol . 2009 Apr; 90(Pt 8):1916-1922. PMID: 19369407
The NS1 gene of influenza A virus encodes a multi-functional protein that plays an important role in counteracting cellular antiviral mechanisms such as the interferon (IFN), protein kinase R and...
8.
Schnettler E, de Vries W, Hemmes H, Haasnoot J, Kormelink R, Goldbach R, et al.
EMBO Rep . 2009 Feb; 10(3):258-63. PMID: 19218918
The question of whether RNA interference (RNAi) acts as an antiviral mechanism in mammalian cells remains controversial. The antiviral interferon (IFN) response cannot easily be distinguished from a possible antiviral...
9.
Haasnoot J, Berkhout B
Handb Exp Pharmacol . 2008 Dec; (189):243-63. PMID: 19048203
For almost three decades, researchers have studied the possibility to use nucleic acids as antiviral therapeutics. In theory, compounds such as antisense oligonucleotides, ribozymes, DNAzymes, and aptamers can be designed...
10.
Brake O, Haasnoot J, Kurreck J, Berkhout B
Retrovirology . 2008 Sep; 5:81. PMID: 18801178
No abstract available.