Joost C M Holthuis
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Explore the profile of Joost C M Holthuis including associated specialties, affiliations and a list of published articles.
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59
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2435
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Recent Articles
1.
Bieker S, Timme M, Woge N, Hassan D, Brown C, Marrink S, et al.
Commun Biol
. 2025 Feb;
8(1):212.
PMID: 39930004
Binding of hexokinase HKI to mitochondrial voltage-dependent anion channels (VDACs) has far-reaching physiological implications. However, the structural basis of this interaction is unclear. Combining computer simulations with experiments in cells,...
2.
Kol M, Novak A, Morstein J, Schroer C, Sokoya T, Mensing S, et al.
J Lipid Res
. 2024 Dec;
66(1):100724.
PMID: 39672331
Sphingolipid metabolism comprises a complex interconnected web of enzymes, metabolites, and modes of regulation that influence a wide range of cellular and physiological processes. Deciphering the biological relevance of this...
3.
Kol M, Novak A, Morstein J, Schroer C, Sokoya T, Mensing S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484495
Sphingolipid metabolism comprises a complex interconnected web of enzymes, metabolites and modes of regulation that influence a wide range of cellular and physiological processes. Deciphering the biological relevance of this...
4.
Listian S, Mazur A, Kol M, Ufelmann E, Eising S, Frohlich F, et al.
iScience
. 2024 Sep;
27(9):110609.
PMID: 39286488
is a professional phagocyte frequently used to study cellular processes underlying the recognition, engulfment, and infection course of microbial pathogens. Sphingolipids are abundant components of the plasma membrane that bind...
5.
Jahn H, Bartos L, Dearden G, Dittman J, Holthuis J, Vacha R, et al.
Nat Commun
. 2023 Dec;
14(1):8115.
PMID: 38065946
Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this...
6.
Koutsogiannis Z, Mina J, Albus C, Kol M, Holthuis J, Pohl E, et al.
FASEB J
. 2023 Oct;
37(11):e23229.
PMID: 37795915
Toxoplasma gondii is an obligate, intracellular apicomplexan protozoan parasite of both humans and animals that can cause fetal damage and abortion and severe disease in the immunosuppressed. Sphingolipids have indispensable...
7.
Guzman G, Farley S, Kyle J, Bramer L, Hoeltzl S, van den Dikkenberg J, et al.
bioRxiv
. 2023 Aug;
PMID: 37546869
Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and...
8.
Barisch C, Holthuis J, Cosentino K
Biol Chem
. 2023 Feb;
404(5):467-490.
PMID: 36810295
Bilayered membranes separate cells from their surroundings and form boundaries between intracellular organelles and the cytosol. Gated transport of solutes across membranes enables cells to establish vital ion gradients and...
9.
Philippi M, Richter C, Kappen M, Watrinet I, Miao Y, Runge M, et al.
Small
. 2022 Oct;
18(50):e2203723.
PMID: 36266931
Qualitative and quantitative analysis of transient signaling platforms in the plasma membrane has remained a key experimental challenge. Here, biofunctional nanodot arrays (bNDAs) are developed to spatially control dimerization and...
10.
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Sokoya T, Parolek J, Foged M, Danylchuk D, Bozan M, Sarkar B, et al.
Elife
. 2022 Sep;
11.
PMID: 36102623
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway....