Jongkyeong Chung
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Explore the profile of Jongkyeong Chung including associated specialties, affiliations and a list of published articles.
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89
Citations
5178
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Recent Articles
1.
Lee D, Yoon E, Ham S, Lee K, Jang H, Woo D, et al.
Nat Commun
. 2024 Jan;
15(1):468.
PMID: 38212312
Diabetic sensory neuropathy (DSN) is one of the most common complications of type 2 diabetes (T2D), however the molecular mechanistic association between T2D and DSN remains elusive. Here we identify...
2.
Ham S, Yoo H, Woo D, Lee D, Park K, Chung J
Nat Commun
. 2023 Aug;
14(1):5202.
PMID: 37626046
Although defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson's disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss...
3.
Kang J, Kim D, Rhee J, Seo J, Park I, Kim J, et al.
PLoS Biol
. 2023 Jul;
21(7):e3002192.
PMID: 37478146
During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) is stabilized and induces expressions of its target genes regulating...
4.
Lee A, Kim C, Park S, Joo J, Choi B, Yang D, et al.
Sci Adv
. 2023 Apr;
9(15):eabo2467.
PMID: 37058563
Parkinson's disease (PD) is a progressive neurodegenerative disorder. However, cell type-dependent transcriptional regulatory programs responsible for PD pathogenesis remain elusive. Here, we establish transcriptomic and epigenomic landscapes of the substantia...
5.
Roh K, Noh J, Kim Y, Jang Y, Kim J, Choi H, et al.
Nat Metab
. 2023 Mar;
5(3):398-413.
PMID: 36864206
Whereas cholesterol is vital for cell growth, proliferation, and remodeling, dysregulation of cholesterol metabolism is associated with multiple age-related pathologies. Here we show that senescent cells accumulate cholesterol in lysosomes...
6.
Na S, Kim K, Jung Y, Kim D, Kim J, Cho S, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613556
The orphan nuclear receptor, estrogen-related receptor γ (ERRγ) is a constitutively active transcription factor involved in mitochondrial metabolism and energy homeostasis. GSK5182, a specific inverse agonist of ERRγ that inhibits...
7.
Kim M, Son G, Cho Y, Kim G, Yoon S, Kim Y, et al.
J Neurogenet
. 2022 Nov;
37(1-2):25-35.
PMID: 36415929
The rhythmic pattern of biological processes controlled by light over 24 h is termed the circadian rhythm. Disturbance of circadian rhythm due to exposure to light at night (LAN) disrupts...
8.
Yoon W, Min S, Ryu H, Chung S, Chung J
Commun Biol
. 2022 Aug;
5(1):872.
PMID: 36008531
Although levodopa is the most effective medication for Parkinson's disease, long-term levodopa treatment is largely compromised due to late motor complications, including levodopa-induced dyskinesia (LID). However, the genetic basis of...
9.
Sonn S, Song E, Seo S, Kim Y, Um J, Yeo F, et al.
Redox Biol
. 2022 Mar;
51:102275.
PMID: 35248828
Mitochondrial quality control (MQC) consists of multiple processes: the prevention of mitochondrial oxidative damage, the elimination of damaged mitochondria via mitophagy and mitochondrial fusion and fission. Several studies proved that...
10.
Ham S, Lee D, Xu W, Cho E, Choi S, Min S, et al.
Sci Adv
. 2021 Jul;
7(28).
PMID: 34244144
The role of ubiquitin carboxyl-terminal hydrolase L1 (; also called ) in the pathogenesis of Parkinson's disease (PD) has been controversial. Here, we find that the loss of UCHL1 destabilizes...