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Jonathon Hinton

Explore the profile of Jonathon Hinton including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 1257
Followers 0
Related Specialties
Genetics
Oncology
Molecular Biology
Top 10 Co-Authors
P Andrew Futreal
Michael R Stratton
Adam Butler
Sarah OMeara
Gemma Buck
Sarah Edkins
Keiran Raine
Sara Widaa
Andrew Menzies
David Jones
Published In
Nat Genet
Am J Hum Genet
Cancer Res
Nature
Genes Chromosomes Cancer
Affiliations
Soon will be listed here.
Recent Articles
1.
Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma
Tarpey P, Behjati S, Cooke S, Van Loo P, Wedge D, Pillay N, et al.
Nat Genet . 2013 Jun; 45(8):923-6. PMID: 23770606
Chondrosarcoma is a heterogeneous collection of malignant bone tumors and is the second most common primary malignancy of bone after osteosarcoma. Recent work has identified frequent, recurrent mutations in IDH1...
2.
Signatures of mutation and selection in the cancer genome
Bignell G, Greenman C, Davies H, Butler A, Edkins S, Andrews J, et al.
Nature . 2010 Feb; 463(7283):893-8. PMID: 20164919
The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous deletions in cancer genomes occur over recessive cancer genes, where they can confer selective growth...
3.
Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus
Raymond F, Tarpey P, Edkins S, Tofts C, OMeara S, Teague J, et al.
Am J Hum Genet . 2007 Apr; 80(5):982-7. PMID: 17436253
We have identified one frameshift mutation, one splice-site mutation, and two missense mutations in highly conserved residues in ZDHHC9 at Xq26.1 in 4 of 250 families with X-linked mental retardation...
4.
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation
Tarpey P, Stevens C, Teague J, Edkins S, OMeara S, Avis T, et al.
Am J Hum Genet . 2006 Dec; 79(6):1119-24. PMID: 17186471
In a systematic sequencing screen of the coding exons of the X chromosome in 250 families with X-linked mental retardation (XLMR), we identified two nonsense mutations and one consensus splice-site...
5.
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
Hunter C, Smith R, Cahill D, Stephens P, Stevens C, Teague J, et al.
Cancer Res . 2006 Apr; 66(8):3987-91. PMID: 16618716
Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent temozolomide after surgical resection and radiotherapy....
6.
Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults
Bignell G, Smith R, Hunter C, Stephens P, Davies H, Greenman C, et al.
Genes Chromosomes Cancer . 2005 Sep; 45(1):42-6. PMID: 16175573
The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations in the KIT receptor tyrosine kinase in testicular germ-cell tumors (TGCT)....
7.
Somatic mutations of the protein kinase gene family in human lung cancer
Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, et al.
Cancer Res . 2005 Sep; 65(17):7591-5. PMID: 16140923
Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We screened the coding sequences of 518 protein kinases...
8.
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Stephens P, Edkins S, Davies H, Greenman C, Cox C, Hunter C, et al.
Nat Genet . 2005 May; 37(6):590-2. PMID: 15908952
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a...