Jonathan Weitz
Overview
Explore the profile of Jonathan Weitz including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
210
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0
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Recent Articles
1.
Weitz J, Nishizaki D, Liau J, Patel J, Ng I, Sun S, et al.
J Clin Oncol
. 2024 Oct;
43(6):705-715.
PMID: 39413348
Purpose: Mucinous neoplasms of the gastrointestinal tract are characterized by a propensity for metastasis to the peritoneum, resulting in peritoneal mucinous carcinomatosis (PMC). A subset of these tumors, most often...
2.
Weitz J
J Vis Exp
. 2023 Aug;
(193).
PMID: 37602853
Delgadillo-Silva, L. F., Akhtar, M. N., Tasoz, E., Ninov, N. Simultaneous calcium imaging and glucose stimulation in living zebrafish to investigate in vivo beta-cell function. Journal of Visualized Experiments. (175),...
3.
Weitz J, Garg B, Martsinkovskiy A, Patel S, Tiriac H, Lowy A
Oncogene
. 2023 Jul;
42(34):2536-2546.
PMID: 37433986
Perineural invasion (PNI) is the phenomenon whereby cancer cells invade the space surrounding nerves. PNI occurs frequently in epithelial malignancies, but is especially characteristic of pancreatic ductal adenocarcinoma (PDAC). The...
4.
Gulay K, Zhang X, Pantazopoulou V, Patel J, Esparza E, Sheik Pran Babu D, et al.
Cancer Res
. 2023 Jun;
83(18):3001-3012.
PMID: 37378556
Significance: KRAS-mutant pancreatic cancer models, including KRAS inhibitor-resistant models, show exquisite sensitivity to combined pan-ERBB and KRAS targeting, which provides the rationale for testing this drug combination in clinical trials.
5.
Rohila D, Park I, Pham T, Weitz J, Hurtado de Mendoza T, Madheswaran S, et al.
Cancer Res
. 2023 Jun;
83(16):2675-2689.
PMID: 37306759
Significance: Syk blockade induces macrophage polarization to an immunostimulatory phenotype, which enhances CD8+ T-cell responses and improves gemcitabine efficacy in pancreatic ductal adenocarcinoma, a clinically challenging malignancy.
6.
Weitz J, Garg B, Tiriac H, Martsinkovskiy A, Patel S, Lowy A
Res Sq
. 2023 Apr;
PMID: 37034696
Perineural invasion (PNI) is the phenomenon whereby cancer cells invade the space surrounding nerves. PNI occurs frequently in epithelial malignancies, but is especially characteristic of pancreatic ductal adenocarcinoma (PDAC). The...
7.
Weitz J, Gulay K, Hurtado de Mendoza T, Tiriac H, Baumgartner J, Kelly K, et al.
J Vis Exp
. 2022 Dec;
(190).
PMID: 36571414
Pseudomyxoma peritonei (PMP) is a rare condition that results from the dissemination of a mucinous primary tumor and the resultant accumulation of mucin-secreting tumor cells in the peritoneal cavity. PMP...
8.
Weitz J, Hurtado de Mendoza T, Tiriac H, Lee J, Sun S, Garg B, et al.
Clin Cancer Res
. 2022 Sep;
28(21):4793-4806.
PMID: 36067351
Purpose: Epithelial neoplasms of the appendix are difficult to study preclinically given their low incidence, frequent mucinous histology, and absence of a comparable organ in mice for disease modeling. Although...
9.
Weitz J, Menegaz D, Caicedo A
Diabetes
. 2020 Dec;
70(1):17-26.
PMID: 33355306
Pancreatic islets are clusters of hormone-secreting endocrine cells that rely on intricate cell-cell communication mechanisms for proper function. The importance of multicellular cooperation in islet cell physiology was first noted...
10.
Makhmutova M, Weitz J, Tamayo A, Pereira E, Boulina M, Almaca J, et al.
Gastroenterology
. 2020 Oct;
160(3):875-888.e11.
PMID: 33121946
Background And Aims: Destroying visceral sensory nerves impacts pancreatic islet function, glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory neurons has not been studied. Methods:...