Jonathan V Sweedler
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Explore the profile of Jonathan V Sweedler including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Okyem S, Mast D, Romanova E, Rubakhin S, Sweedler J
Commun Chem
. 2025 Mar;
8(1):72.
PMID: 40057589
The isoaspartate residue is a spontaneous, time-dependent post-translational modification (PTM) of proteins and peptides, associated with in vivo protein aggregation and changes in molecule lifetime. While this is considered a...
2.
Dong J, Croslow S, Lane S, Castro D, Blanford J, Zhou S, et al.
Plant Cell
. 2025 Feb;
37(2).
PMID: 39899469
Plant bioengineering is a time-consuming and labor-intensive process with no guarantee of achieving desired traits. Here, we present a fast, automated, scalable, high-throughput pipeline for plant bioengineering (FAST-PB) in maize...
3.
Bell S, Xie Y, Maciejewski M, Rubakhin S, Romanova E, Bell A, et al.
J Proteome Res
. 2025 Jan;
PMID: 39792146
Variation in parenting behavior is widespread across the animal kingdom, both within and between species. There are two ecotypes of the three-spined stickleback fish () that exhibit dramatic differences in...
4.
Fink M, Weaver A, Parmar D, Paczkowski J, Li L, Klaers M, et al.
mBio
. 2024 Dec;
16(2):e0332024.
PMID: 39727421
Importance: While we now appreciate that many infections are polymicrobial, we understand little of the specific actions between a given set of microbes to enable combinatorial survival and pathogenesis. The...
5.
Murphy S, Sullivan-Weiss A, Sirois C, Rubakhin S, Kong H, Gillette M, et al.
ACS Chem Neurosci
. 2024 Dec;
16(1):30-39.
PMID: 39692746
Organoids are multicellular structures formed from populations of individual cells allowing modeling of structural and functional aspects of organs and tissues in normal and diseased states. They offer unique opportunities...
6.
Okyem S, Sweedler J
Mass Spectrom Rev
. 2024 Nov;
PMID: 39558451
One of the great triumphs of mass spectrometry-based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the...
7.
Fink M, Weaver A, Parmar D, Paczkowski J, Li L, Klaers M, et al.
bioRxiv
. 2024 Nov;
PMID: 39484380
The bacterium is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While is known to exhibit a robust competitive response towards other bacterial...
8.
Subramanian C, McNamara K, Croslow S, Tan Y, Hess D, Kiseljak-Vassiliades K, et al.
Surgery
. 2024 Oct;
177:108832.
PMID: 39424480
Background: Recent multigenomic analysis of adrenocortical carcinomas (ACCs) identified SLC7A11/xCT as a novel biomarker. The Food and Drug Administration-approved anti-inflammatory drug, sulfasalazine (SAS), induces ferroptosis by blocking SLC7A11 expression. We...
9.
Zhao Y, Park I, Rubakhin S, Bashir R, Vlasov Y, Sweedler J
Anal Chim Acta
. 2024 Aug;
1321:342998.
PMID: 39155094
Background: Droplet microfluidics with push-pull and microdialysis sampling from brain slices, cultured cells and engineered tissues produce low volume mass limited samples containing analytes sampled from the extracellular space. This...
10.
Mao R, Guo S, Zhang G, Li Y, Xu J, Wang H, et al.
J Biol Chem
. 2024 Jul;
300(8):107556.
PMID: 39002683
Diversity, a hallmark of G protein-coupled receptor (GPCR) signaling, partly stems from alternative splicing of a single gene generating more than one isoform for a receptor. Additionally, receptor responses to...