Jonathan Soboloff
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Explore the profile of Jonathan Soboloff including associated specialties, affiliations and a list of published articles.
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79
Citations
3855
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Recent Articles
1.
Ray S, McCall J, Tian J, Jeon J, Douglas A, Tyler K, et al.
Sci Adv
. 2025 Jan;
11(3):eabm9843.
PMID: 39813349
Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca-selective ion channel, Orai1, is critical for osteoclast maturation. Here,...
2.
Zaidi M, Soboloff J
Cell Calcium
. 2024 Dec;
125():102989.
PMID: 39740384
Recent findings by Abrahamian et al. (2024) provides new insights into the relationship between Two Pore Channel 2 (TPC2) activity and the development and progression of melanoma. Melanocyte inducing transcription...
3.
Blair H, Soboloff J, Tourkova I, McCall J, Ray S, Rosenkranz M, et al.
Front Biosci (Landmark Ed)
. 2024 Jul;
29(7):248.
PMID: 39082340
We review the abnormal bone turnover that is the basis of idiopathic inflammatory or rheumatoid arthritis and bone loss, with emphasis on Tumor Necrosis Factor-alpha (TNFα)-related mechanisms. We review selected...
4.
McCall J, Geldenhuys W, Robinson L, Witt M, Gannett P, Soderberg B, et al.
Pharmacol Res Perspect
. 2024 Jun;
12(4):e1230.
PMID: 38940379
This study provides a detailed understanding of the preclinical pharmacokinetics and metabolism of ELP-004, an osteoclast inhibitor in development for the treatment of bone erosion. Current treatments for arthritis, including...
5.
Stutzmann G, Soboloff J
J Physiol
. 2024 Apr;
602(8):1445-1447.
PMID: 38578234
No abstract available.
6.
Smit R, Ghosh B, Campion 3rd T, Stingel R, Lavell E, Hooper R, et al.
Brain Res
. 2023 Nov;
1824:148691.
PMID: 38030102
Introduction: Parkinson's disease (PD) is the most prevalent disorder of the basal ganglia, propagated by the degeneration of axon terminals within the striatum and subsequent loss of dopaminergic neurons in...
7.
Ogier C, Solomon A, Lu Z, Recoules L, Klochkova A, Gabitova-Cornell L, et al.
bioRxiv
. 2023 Sep;
PMID: 37745612
In pancreatic ductal adenocarcinoma (PDAC), the fibroblastic stroma constitutes most of the tumor mass and is remarkably devoid of functional blood vessels. This raises an unresolved question of how PDAC...
8.
Gross S, Womer L, Kappes D, Soboloff J
Trends Biochem Sci
. 2023 Sep;
48(12):1083-1097.
PMID: 37696713
In T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for...
9.
Dutta Banik D, Martin L, Tang T, Soboloff J, Tourtellotte W, Pierchala B
Proc Natl Acad Sci U S A
. 2023 May;
120(22):e2217595120.
PMID: 37216536
The sense of taste starts with activation of receptor cells in taste buds by chemical stimuli which then communicate this signal via innervating oral sensory neurons to the CNS. The...
10.
Robinson L, Soboloff J, Tourkova I, Larrouture Q, Onwuka K, Papachristou D, et al.
PLoS One
. 2023 May;
18(5):e0264596.
PMID: 37167218
The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1...