Jonathan R Brent
Overview
Explore the profile of Jonathan R Brent including associated specialties, affiliations and a list of published articles.
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7
Citations
235
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0
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Recent Articles
1.
Brent J, Deng H
J Clin Invest
. 2023 May;
133(10).
PMID: 37183815
Spastic paraplegia 50 (SPG50) is a rare neurodegenerative disease caused by loss-of-function mutations in AP4M1. There are no effective treatments for SPG50 or any other type of SPG, and current...
2.
Baron D, Fenton A, Saez-Atienzar S, Giampetruzzi A, Sreeram A, Shankaracharya , et al.
Cell Rep
. 2022 Apr;
39(1):110598.
PMID: 35385738
Understanding the pathogenic mechanisms of disease mutations is critical to advancing treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A result in skipping of exon 27 (KIF5A) and...
3.
Brent J, Ajroud-Driss S
Pract Neurol (Fort Wash Pa)
. 2021 Mar;
18:46-49.
PMID: 33746637
No abstract available.
4.
Brent J, Ozdinler P
SOJ Neurol
. 2021 Mar;
4(1):1-3.
PMID: 33693055
Recent advances in the genetics of ALS have bolstered hope that a molecular logic for the pathogenesis of the disease is fast approaching. An emerging challenge is the dissection of...
5.
Brent J, Franz C, Coleman 3rd J, Ajroud-Driss S
Neurol Clin
. 2020 Jul;
38(3):565-575.
PMID: 32703469
Amyotrophic lateral sclerosis (ALS) is a fatal disease with no cure; however, symptomatic management has an impact on quality of life and survival. Symptom management is best performed in a...
6.
Wang J, Brent J, Tomlinson A, Shneider N, McCabe B
J Clin Invest
. 2011 Sep;
121(10):4118-26.
PMID: 21881207
The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD), an early-onset neurodegenerative disorder. The RNA/DNA-binding proteins fused in sarcoma...
7.
Brent J, Werner K, McCabe B
J Vis Exp
. 2009 Feb;
(24).
PMID: 19229190
The Drosophila neuromuscular junction (NMJ) is an established model system used for the study of synaptic development and plasticity. The widespread use of the Drosophila motor system is due to...