Jonathan Pacheco
Overview
Explore the profile of Jonathan Pacheco including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
355
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Recent Articles
1.
Pacheco J, Pena K, Savransky S, Gidon A, Hammond G, Janetzko J, et al.
Nat Commun
. 2024 Dec;
15(1):10499.
PMID: 39627206
The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling. We...
2.
Wills R, Doyle C, Zewe J, Pacheco J, Hansen S, Hammond G
J Cell Sci
. 2023 Aug;
136(16).
PMID: 37534432
The lipid molecule phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] controls all aspects of plasma membrane (PM) function in animal cells, from its selective permeability to the attachment of the cytoskeleton. Although disruption of...
3.
Pacheco J, Sampieri A, Vaca L
Cell Calcium
. 2023 May;
112:102742.
PMID: 37126913
STIM1 and Orai1 are the central core of the Store Operated Calcium Entry (SOCE). This calcium influx mechanism is triggered after the activation of Gq protein-coupled receptors at the plasma...
4.
Pacheco J, Bohorquez-Hernandez A, Mendez-Acevedo K, Sampieri A, Vaca L
Adv Exp Med Biol
. 2023 Mar;
1422:305-326.
PMID: 36988886
Calcium is one of the most prominent second messengers. It is involved in a wide range of functions at the single-cell level but also in modulating regulatory mechanisms in the...
5.
PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes
Pacheco J, Cassidy A, Zewe J, Wills R, Hammond G
J Cell Biol
. 2022 Nov;
222(2).
PMID: 36416724
The lipid phosphatidyl-D-myo-inositol-4,5-bisphosphate [PI(4,5)P2] is a master regulator of plasma membrane (PM) function. Its effector proteins regulate transport, signaling, and cytoskeletal processes that define PM structure and function. How a...
6.
Walpole G, Pacheco J, Chauhan N, Clark J, Anderson K, Abbas Y, et al.
Nat Cell Biol
. 2022 Apr;
24(5):708-722.
PMID: 35484249
Despite their low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P and PtdIns(3,4)P are uniquely important, as they promote cell growth, survival and migration. Pathogenic organisms...
7.
Vyas A, Gomez-Casal R, Cruz-Rangel S, Villanueva H, Sikora A, Rajagopalan P, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(12):e2100670119.
PMID: 35286200
Squamous cell carcinoma of the head and neck (SCCHN) is a devastating disease that continues to have low cure rates despite the recent advances in therapies. Cisplatin is the most...
8.
Pacheco J, Wills R, Hammond G
Methods Mol Biol
. 2021 Jan;
2251:105-120.
PMID: 33481234
Chemical dimerization systems have been used to drive acute depletion of polyphosphoinsitides (PPIns). They do so by inducing subcellular localization of enzymes that catabolize PPIns. By using this approach, all...
9.
Wills R, Pacheco J, Hammond G
Methods Mol Biol
. 2021 Jan;
2251:55-72.
PMID: 33481231
Lipids, like phosphoinositides, can be visualized in living cells in real time using genetically encoded biosensors and fluorescence microscopy. Sensor localization can be quantified by determining the fluorescence intensity of...
10.
Rosendo-Pineda M, Vicente J, Vivas O, Pacheco J, Loza-Huerta A, Sampieri A, et al.
Commun Biol
. 2020 Nov;
3(1):665.
PMID: 33184446
N-methyl-D-aspartate receptors (NMDAR) are glutamate-gated calcium channels named after their artificial agonist. NMDAR are implicated in cell proliferation under normal and pathophysiological conditions. However, the role of NMDAR during mitosis...