Jonathan OKeeffe Ahern
Overview
Explore the profile of Jonathan OKeeffe Ahern including associated specialties, affiliations and a list of published articles.
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5
Citations
71
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Recent Articles
1.
OKeeffe Ahern J, Lara-Saez I, Zhou D, Murillas R, Bonafont J, Mencia A, et al.
Gene Ther
. 2021 Aug;
29(3-4):157-170.
PMID: 34363036
Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an efficient and safe delivery system into cells and tissues continues to hinder clinical translation...
2.
OKeeffe Ahern J, A S, Zhou D, Gao Y, Lyu J, Meng Z, et al.
Biomacromolecules
. 2017 Nov;
19(5):1410-1415.
PMID: 29125281
Using a combined synthesis approach comprising reversible addition-fragmentation transfer polymerization and ring opening reaction, a series of poly glycidyl methacrylate (polyGMA) polymers were designed and synthesized for gene delivery. These...
3.
Zhou D, Pierucci L, Gao Y, OKeeffe Ahern J, Huang X, Sigen A, et al.
ACS Appl Mater Interfaces
. 2017 Feb;
9(7):5793-5802.
PMID: 28170215
We report a new type of thermo- and pH-responsive, coacervate-forming highly degradable polymer-hyperbranched poly(β-amino esters) (HPAEs) and its selective cell binding behaviors. The HPAEs were synthesized from 5-amino-1-pentanol (S5) and...
4.
Zhou D, Gao Y, OKeeffe Ahern J, A S, Xu Q, Huang X, et al.
ACS Appl Mater Interfaces
. 2016 Dec;
8(50):34218-34226.
PMID: 27998152
One of the most significant challenges in the development of polymer materials for gene delivery is to understand how topological structure influences their transfection properties. Poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32) has proven...
5.
Gao Y, Huang J, OKeeffe Ahern J, Cutlar L, Zhou D, Lin F, et al.
Biomacromolecules
. 2016 Sep;
17(11):3640-3647.
PMID: 27641634
A successful polymeric gene delivery vector is denoted by both transfection efficiency and biocompatibility. However, the existing vectors with combined high efficacy and minimal toxicity still fall short. The most...