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Xiaobei Huang

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Articles 16
Citations 64
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Recent Articles
1.
Xiang Y, Qiu Z, Ding Y, Du M, Gao N, Cao H, et al.
J Control Release . 2024 Jul; 372:874-884. PMID: 38977133
Dexamethasone (DEX) has been demonstrated to inhibit the inflammatory corneal neovascularization (CNV). However, the therapeutic efficacy of DEX is limited by the poor bioavailability of conventional eye drops and the...
2.
Zhu L, Zhong Y, Yan M, Ni S, Zhao X, Wu S, et al.
ACS Appl Mater Interfaces . 2024 Jun; 16(25):32027-32044. PMID: 38867426
Atherosclerotic plaques exhibit high cholesterol deposition and oxidative stress resulting from high reactive oxygen species (ROS). These are the major components in plaques and the main pro-inflammatory factor. Therefore, it...
3.
Ma Y, Yi J, Ruan J, Ma J, Yang Q, Zhang K, et al.
Adv Healthc Mater . 2024 Apr; 13(20):e2400514. PMID: 38652681
Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood-brain barrier (BBB), which restrict the effectiveness of traditional treatments like...
4.
Huang X, Mu N, Ding Y, Huang R, Wu W, Li L, et al.
J Control Release . 2023 Dec; 366:194-203. PMID: 38142965
Glioblastoma multiforme (GBM) is one of the most common primary intracranial tumors in the central nervous system with poor prognosis, high invasiveness, risk of recurrence and low survival rate. Thus,...
5.
Hu S, Xia K, Huang X, Zhao Y, Zhang Q, Huang D, et al.
J Nanobiotechnology . 2023 Sep; 21(1):353. PMID: 37773145
Colorectal cancer (CRC) is a major cause of cancer-related deaths in humans, and effective treatments are still needed in clinical practice. Despite significant developments in anticancer drugs and inhibitors, their...
6.
Huang X, Zhou D, Zeng M, Alshehri F, Li X, OKeeffe-Ahern J, et al.
ACS Macro Lett . 2022 Jun; 6(6):575-579. PMID: 35650840
Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery...
7.
Huang X, Mu N, Ding Y, Lam H, Yue L, Gao C, et al.
Acta Biomater . 2022 May; 147:356-365. PMID: 35577046
Nanoparticles (NPs) modified with targeting ligands have often shown great potential in targeted drug delivery for tumor therapy. However, the clearance of NPs by the monocyte-phagocyte system (MPS) and the...
8.
Li Q, Sun L, Huang X, Liu S, Yong H, Wang C, et al.
ACS Macro Lett . 2022 May; 11(5):636-642. PMID: 35570814
Biodegradable and lipid-like highly branched poly(β-amino ester)s, HPAESA, were developed to enhance the biological functions of adipose-derived stem cells by gene transfection. Biodegradability reduces the cytotoxicity of HPAESA and enables...
9.
Xu N, Huang X, Yin G, Bu M, Pu X, Chen X, et al.
RSC Adv . 2022 May; 8(28):15604-15612. PMID: 35539452
In contrast with traditional chemotherapy, controlled drug delivery systems provide many advantages. Herein, a thermosensitive star polymer pompon with a core-arm structure was synthesized using a grafting-on method as a...
10.
Wang C, Huang X, Sun L, Li Q, Li Z, Yong H, et al.
Chem Commun (Camb) . 2022 Jan; 58(13):2136-2139. PMID: 35040830
Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs...