Jonathan Nakashima
Overview
Explore the profile of Jonathan Nakashima including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
344
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0
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Recent Articles
1.
Al Shihabi A, Tebon P, Nguyen H, Chantharasamee J, Sartini S, Davarifar A, et al.
Cell Stem Cell
. 2024 Sep;
31(10):1524-1542.e4.
PMID: 39305899
Sarcomas are rare malignancies with over 100 distinct histological subtypes. Their rarity and heterogeneity pose significant challenges to identifying effective therapies, and approved regimens show varied responses. Novel, personalized approaches...
2.
Rajan R, Fernandez-Vega V, Sperry J, Nakashima J, Do L, Andrews W, et al.
Cancers (Basel)
. 2023 Jul;
15(13).
PMID: 37444398
Background: Genomic profiling cannot solely predict the complexity of how tumor cells behave in their in vivo microenvironment and their susceptibility to therapies. The aim of the study was to...
3.
Chin D, Osman I, Porch J, Kim H, Buck K, Rodriguez J, et al.
Pharmaceuticals (Basel)
. 2023 Jun;
16(2).
PMID: 37259348
Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other...
4.
Laks D, Oses-Prieto J, Alvarado A, Nakashima J, Chand S, Azzam D, et al.
Neuro Oncol
. 2017 Nov;
20(6):764-775.
PMID: 29136244
Background: Clinical trials of therapies directed against nodes of the signaling axis of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin (mTOR) in glioblastoma (GBM) have had disappointing results. Resistance to mTOR inhibitors...
5.
Schubbert S, Jiao J, Ruscetti M, Nakashima J, Wu S, Lei H, et al.
Methods Mol Biol
. 2016 Apr;
1388:233-85.
PMID: 27033080
PTEN (phosphatase and tensin homologue) is the first tumor suppressor identified to have phosphatase activity and its gene is the second most frequently deleted or mutated tumor-suppressor gene associated with...
6.
Shurell E, Tran L, Nakashima J, Smith K, Tam B, Li Y, et al.
BMC Cancer
. 2014 Nov;
14:827.
PMID: 25398666
Background: Gender-based differences in disease onset in murine models of malignant peripheral nerve sheath tumor (MPNST) and in patients with Neurofibromatosis type-1-(NF-1)-associated or spontaneous MPNST has not been well studied....
7.
Hsia H, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(36):13205-10.
PMID: 25157163
Protein ubiquitination is a core regulatory determinant of neural development. Previous studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN)...
8.
Lazovic J, Guo L, Nakashima J, Mirsadraei L, Yong W, Kim H, et al.
Neuro Oncol
. 2014 Jul;
17(1):53-62.
PMID: 25074541
Background: Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and in vivo using glioma cell...
9.
Gregorian C, Nakashima J, Dry S, Nghiemphu P, Smith K, Ao Y, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(46):19479-84.
PMID: 19846776
Patients with neurofibromatosis type 1 (NF1) carry approximately a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST). Although the molecular mechanisms underlying NF1 to MPNST malignant...
10.
Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, et al.
J Neurosci
. 2009 Feb;
29(6):1874-86.
PMID: 19211894
Here we show that conditional deletion of Pten in a subpopulation of adult neural stem cells in the subependymal zone (SEZ) leads to persistently enhanced neural stem cell self-renewal without...