Jonathan Mangion
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Explore the profile of Jonathan Mangion including associated specialties, affiliations and a list of published articles.
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13
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739
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Recent Articles
1.
Lee C, Lin J, Prokop A, Gopalakrishnan V, Hanna R, Papa E, et al.
Front Genet
. 2022 Jun;
13:868015.
PMID: 35711912
Target prioritization is essential for drug discovery and repositioning. Applying computational methods to analyze and process multi-omics data to find new drug targets is a practical approach for achieving this....
2.
McGinn S, Bauer D, Brefort T, Dong L, El-Sagheer A, ElSharawy A, et al.
N Biotechnol
. 2015 Oct;
33(3):311-30.
PMID: 26514324
The REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) project received funding from the European Commission for 41/2 years. The objectives of the project revolved around technological developments in...
3.
Jiao X, Rosenlund M, Hooper S, Tellgren-Roth C, He L, Fu Y, et al.
PLoS One
. 2011 Jul;
6(7):e22250.
PMID: 21799804
Comprehensive identification of the acquired mutations that cause common cancers will require genomic analyses of large sets of tumor samples. Typically, the tissue material available from tumor specimens is limited,...
4.
Fernando M, de Smith A, Coin L, Morris D, Froguel P, Mangion J, et al.
Ann Hum Genet
. 2011 Mar;
75(3):383-97.
PMID: 21401563
We undertook a candidate locus study of the HIN200 gene cluster on 1q21-23 in UK systemic lupus erythematosus (SLE) families. To date, despite mounting evidence demonstrating the importance of these...
5.
Motallebipour M, Ameur A, Reddy Bysani M, Patra K, Wallerman O, Mangion J, et al.
Genome Biol
. 2009 Nov;
10(11):R129.
PMID: 19919681
Background: The forkhead box/winged helix family members FOXA1, FOXA2, and FOXA3 are of high importance in development and specification of the hepatic linage and the continued expression of liver-specific genes....
6.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, et al.
BMC Biol
. 2009 Oct;
7:70.
PMID: 19874574
Background: We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH...
7.
Grieve I, Dickens N, Pravenec M, Kren V, Hubner N, Cook S, et al.
PLoS One
. 2008 Dec;
3(12):e4033.
PMID: 19112506
Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis- and trans-acting, reflecting local and distant regulation of gene expression respectively. Although...
8.
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Petretto E, Sarwar R, Grieve I, Lu H, Kumaran M, Muckett P, et al.
Nat Genet
. 2008 Apr;
40(5):546-52.
PMID: 18443592
Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined...
9.
Bhave S, Hornbaker C, Phang T, Saba L, Lapadat R, Kechris K, et al.
BMC Genet
. 2007 Sep;
8:59.
PMID: 17760997
Background: With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts of data. Managing this diverse data and integrating with other biological data are...
10.
Petretto E, Mangion J, Dickens N, Cook S, Kumaran M, Lu H, et al.
PLoS Genet
. 2006 Oct;
2(10):e172.
PMID: 17054398
Variation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling...