Jonathan L Huot
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Explore the profile of Jonathan L Huot including associated specialties, affiliations and a list of published articles.
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15
Citations
116
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Recent Articles
1.
Shikha S, Huot J, Schneider A, Niemann M
Nucleic Acids Res
. 2020 Nov;
48(21):12269-12281.
PMID: 33231678
Mitochondrial tRNA import is widespread, but mechanistic insights of how tRNAs are translocated across mitochondrial membranes remain scarce. The parasitic protozoan T. brucei lacks mitochondrial tRNA genes. Consequently, it imports...
2.
Huot J, Shikha S, Schneider A
Sci Rep
. 2019 Jul;
9(1):10836.
PMID: 31346230
Orthogonal aminoacyl-tRNA synthetase/tRNA pairs have emerged as powerful means of site-specifically introducing non-standard amino acids into proteins in vivo. Using amino acids with crosslinking moieties this method allows the identification...
3.
Harsman A, Oeljeklaus S, Wenger C, Huot J, Warscheid B, Schneider A
Nat Commun
. 2017 Jul;
8:16123.
PMID: 28665399
This corrects the article DOI: 10.1038/ncomms13707.
4.
Harsman A, Oeljeklaus S, Wenger C, Huot J, Warscheid B, Schneider A
Nat Commun
. 2016 Dec;
7:13707.
PMID: 27991487
Mitochondrial protein import is essential for all eukaryotes. Here we show that the early diverging eukaryote Trypanosoma brucei has a non-canonical inner membrane (IM) protein translocation machinery. Besides TbTim17, the...
5.
Laporte D, Huot J, Bader G, Enkler L, Senger B, Becker H
FEBS Lett
. 2014 Oct;
588(23):4268-78.
PMID: 25315413
Aminoacyl-tRNA synthetases (aaRSs) are ubiquitous and ancient enzymes, mostly known for their essential role in generating aminoacylated tRNAs. During the last two decades, many aaRSs have been found to perform...
6.
Araiso Y, Huot J, Sekiguchi T, Frechin M, Fischer F, Enkler L, et al.
Nucleic Acids Res
. 2014 Apr;
42(9):6052-63.
PMID: 24692665
Yeast mitochondrial Gln-mtRNAGln is synthesized by the transamidation of mischarged Glu-mtRNAGln by a non-canonical heterotrimeric tRNA-dependent amidotransferase (AdT). The GatA and GatB subunits of the yeast AdT (GatFAB) are well...
7.
Huot J, Enkler L, Megel C, Karim L, Laporte D, Becker H, et al.
Biochimie
. 2014 Jan;
100:95-106.
PMID: 24440477
Mitochondria originate from the α-proteobacterial domain of life. Since this unique event occurred, mitochondrial genomes of protozoans, fungi, plants and metazoans have highly derived and diverged away from the common...
8.
Fischer F, Huot J, Lorber B, Diss G, Hendrickson T, Becker H, et al.
Nucleic Acids Res
. 2012 Feb;
40(11):4965-76.
PMID: 22362756
Helicobacter pylori catalyzes Asn-tRNA(Asn) formation by use of the indirect pathway that involves charging of Asp onto tRNA(Asn) by a non-discriminating aspartyl-tRNA synthetase (ND-AspRS), followed by conversion of the mischarged...
9.
Huot J, Fischer F, Corbeil J, Madore E, Lorber B, Diss G, et al.
Nucleic Acids Res
. 2011 Aug;
39(21):9306-15.
PMID: 21813455
In many bacteria and archaea, an ancestral pathway is used where asparagine and glutamine are formed from their acidic precursors while covalently linked to tRNA(Asn) and tRNA(Gln), respectively. Stable complexes...
10.
Balg C, De Mieri M, Huot J, Blais S, Lapointe J, Chenevert R
Bioorg Med Chem
. 2010 Oct;
18(22):7868-72.
PMID: 20943400
Genomic studies revealed the absence of glutaminyl-tRNA synthetase and/or asparaginyl-tRNA synthetase in many bacteria and all known archaea. In these microorganisms, glutaminyl-tRNA(Gln) (Gln-tRNA(Gln)) and/or asparaginyl-tRNA(Asn) (Asn-tRNA(Asn)) are synthesized via an...