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Jonathan K Alder

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Recent Articles
21.
Snyder M, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, et al.
J Exp Med . 2022 Mar; 219(4). PMID: 35285873
Acute cellular rejection is common after lung transplantation and is associated with an increased risk of early chronic rejection. We present combined single-cell RNA and TCR sequencing on recipient-derived T...
22.
Alder J, Sutton R, Iasella C, Nouraie M, Koshy R, Hannan S, et al.
J Heart Lung Transplant . 2021 Dec; 41(5):654-663. PMID: 34933798
Background: Idiopathic pulmonary fibrosis (IPF) is the most common indication for lung transplantation in North America and variants in telomere-maintenance genes are the most common identifiable cause of IPF. We...
23.
Yu J, Xu C, Lee J, Alder J, Wen Z, Wang G, et al.
Am J Physiol Lung Cell Mol Physiol . 2021 Jul; 321(4):L653-L662. PMID: 34318693
Uncontrolled donation after cardiac death (uDCD) contributes little to ameliorating donor lung shortage due to rapidly progressive warm ischemia after circulatory arrest. Here, we demonstrated that nonhypoxia improves donor lung...
24.
Penaloza H, Olonisakin T, Bain W, Qu Y, van der Geest R, Zupetic J, et al.
mBio . 2021 Apr; 12(2). PMID: 33824208
Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary infection. To be fully active, IL-36γ is cleaved at its N-terminal...
25.
Sullivan D, Jiang M, Hinchie A, Roth M, Bahudhanapati H, Nouraie M, et al.
Front Med (Lausanne) . 2021 Feb; 8:600626. PMID: 33634147
Cellular senescence due to telomere dysfunction has been hypothesized to play a role in age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been postulated that paracrine mediators originating from...
26.
Valenzi E, Yang H, Sembrat J, Yang L, Winters S, Nettles R, et al.
Thorax . 2020 Dec; 76(3):239-247. PMID: 33268457
Background: Lung microbiota profiles in patients with early idiopathic pulmonary fibrosis (IPF) have been associated with disease progression; however, the topographic heterogeneity of lung microbiota and their roles in advanced...
27.
Li X, Kim S, Chen T, Wang J, Yang X, Tabib T, et al.
FASEB J . 2020 Jun; 34(8):9884-9898. PMID: 32596871
Idiopathic pulmonary fibrosis (IPF) is characterized by altered epithelial cell phenotypes, which are associated with myofibroblast accumulation in the lung. Atypical alveolar epithelial cells in IPF express molecular markers of...
28.
Jiang M, Roth M, Chun-On P, Sullivan D, Alder J
Am J Respir Cell Mol Biol . 2020 Mar; 62(6):692-698. PMID: 32208105
Type II alveolar epithelial cells (AEC2s) play an essential role in the function and maintenance of the pulmonary epithelium. Several transgenic mice have been developed to study the function of...
29.
Iasella C, Winters S, Kois A, Cho J, Hannan S, Koshy R, et al.
Am J Transplant . 2019 Dec; 20(5):1439-1446. PMID: 31874120
Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder (EBV-PTLD) is a serious complication in lung transplant recipients (LTRs) associated with significant mortality. We performed a single-center retrospective study to evaluate the risks...
30.
Zhang Y, Jiang M, Nouraie M, Roth M, Tabib T, Winters S, et al.
Am J Physiol Lung Cell Mol Physiol . 2019 Aug; 317(4):L510-L521. PMID: 31432710
Idiopathic pulmonary fibrosis (IPF) is the most common and devastating of the interstitial lung diseases. Epithelial dysfunction is thought to play a prominent role in disease pathology, and we sought...