Jonathan K Alder
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Explore the profile of Jonathan K Alder including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Thomas S, Niemeyer B, Jimenez-Valdes R, Kaiser A, Espinosa J, Sullivan K, et al.
iScience
. 2023 Aug;
26(8):107361.
PMID: 37554445
Individuals with Down syndrome (DS) clinically manifest severe respiratory illnesses; however, there is a paucity of data on how DS influences homeostatic physiology of lung airway, and its reactive responses...
12.
Snyder M, Anderson M, Benvenuto L, Sutton R, Bondonese A, Koshy R, et al.
J Heart Lung Transplant
. 2023 Aug;
42(12):1666-1677.
PMID: 37544465
Background: Most idiopathic pulmonary fibrosis (IPF) lung transplant recipients (IPF-LTRs) have short telomere (ST) length. Inherited mutations in telomere-related genes are associated with the development of T cell immunodeficiency. Despite...
13.
Gurkar A, Gerencser A, Mora A, Nelson A, Zhang A, Lagnado A, et al.
Nat Aging
. 2023 Jul;
3(7):776-790.
PMID: 37400722
Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to mapping senescent cells in tissues such as the absence of specific markers and their...
14.
Hannan S, Iasella C, Sutton R, Popescu I, Koshy R, Burke R, et al.
Am J Transplant
. 2023 Jul;
23(10):1590-1602.
PMID: 37392813
Idiopathic pulmonary fibrosis lung transplant recipients (IPF-LTRs) are enriched for short telomere length (TL) and telomere gene rare variants. A subset of patients with nontransplant short-TL are at increased risk...
15.
Xie B, Murali A, Vandevender A, Chen J, Silva A, Bello F, et al.
iScience
. 2022 Dec;
25(12):105569.
PMID: 36465107
Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese...
16.
Chun-On P, Hinchie A, Beale H, Gil Silva A, Rush E, Sander C, et al.
Science
. 2022 Nov;
378(6620):664-668.
PMID: 36356143
Overcoming replicative senescence is an essential step during oncogenesis, and the reactivation of through promoter mutations is a common mechanism. promoter mutations are acquired in about 75% of melanomas but...
17.
Sutton R, Trejo Bittar H, Sullivan D, Silva A, Bahudhanapati H, Parikh A, et al.
Hum Mutat
. 2022 Sep;
43(12):2091-2101.
PMID: 36135709
The role of constitutional genetic defects in idiopathic pulmonary fibrosis (IPF) is increasingly appreciated. Monogenic disorders associated with IPF affect two pathways: telomere maintenance, accounting for approximately 10% of all...
18.
Das A, Wang X, Wei J, Hoji A, Coon T, Popescu I, et al.
J Immunol
. 2022 Sep;
209(9):1788-1795.
PMID: 36113884
Chronic lung allograft dysfunction is the major barrier to long-term survival in lung transplant recipients. Evidence supports type 1 alloimmunity as the predominant response in acute/chronic lung rejection, but the...
19.
Alder J, Armanios M
Physiol Rev
. 2022 May;
102(4):1703-1720.
PMID: 35532056
Parenchymal lung disease is the fourth leading cause of death in the United States; among the top causes, it continues on the rise. Telomeres and telomerase have historically been linked...
20.
Popescu I, Snyder M, Iasella C, Hannan S, Koshy R, Burke R, et al.
Am J Respir Crit Care Med
. 2022 Mar;
205(12):1403-1418.
PMID: 35348444
Lymphopenia is common in severe coronavirus disease (COVID-19), yet the immune mechanisms are poorly understood. As inflammatory cytokines are increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we...