Jonas Heilskov Graversen
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Explore the profile of Jonas Heilskov Graversen including associated specialties, affiliations and a list of published articles.
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31
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621
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Recent Articles
1.
Etzerodt A, Mikkelsen J, Torvund-Jensen M, Hennig D, Boesen T, Graversen J, et al.
Nat Commun
. 2024 Dec;
15(1):10871.
PMID: 39738064
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron. In the bloodstream, hemoglobin is bound by haptoglobin, leading...
2.
Skytthe M, Pedersen F, Wernberg C, Indira Chandran V, Krag A, Di Caterino T, et al.
Gastro Hep Adv
. 2024 Aug;
2(5):711-720.
PMID: 39129874
Background And Aims: Macrophages play an important role in the development of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). In this study, we investigated the...
3.
Larsen D, Kaczmarek J, Palarasah Y, Graversen J, Hojrup P
Biochim Biophys Acta Proteins Proteom
. 2024 Mar;
1872(4):141011.
PMID: 38499233
Understanding protein-protein interactions is crucial for drug design and investigating biological processes. Various techniques, such as CryoEM, X-ray spectroscopy, linear epitope mapping, and mass spectrometry-based methods, can be employed to...
4.
Mikkelsen J, Stodkilde K, Jensen M, Hansen A, Wu Q, Lorentzen J, et al.
J Immunol
. 2024 Feb;
212(8):1334-1344.
PMID: 38391367
Various subspecies of the unicellular parasite Trypanosoma brucei cause sleeping sickness, a neglected tropical disease affecting millions of individuals and domestic animals. Immune evasion mechanisms play a pivotal role in...
5.
Lund H, Hunt M, Kurtovic Z, Sandor K, Kagy P, Fereydouni N, et al.
J Exp Med
. 2023 Dec;
221(2).
PMID: 38117255
In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have largely been explored in the context of pain, nerve injury, and repair. However, we discovered that most...
6.
Skytthe M, Sorensen A, Hennig D, Sandberg M, Rasmussen L, Moller H, et al.
Scand J Clin Lab Invest
. 2022 Sep;
82(6):467-473.
PMID: 36129425
Haptoglobin (Hp) is an abundant plasma protein scavenging hemoglobin (Hb) CD163 on macrophages. This process consumes Hp, which therefore negatively correlates to hemolysis. However, exact measurements of Hp plasma levels...
7.
Skytthe M, Sorensen A, Hennig D, Sandberg M, Rasmussen L, Hojrup P, et al.
Scand J Clin Lab Invest
. 2022 Sep;
82(6):461-466.
PMID: 36129375
Haptoglobin-related protein (Hpr) is a plasma protein with high sequence similarity to haptoglobin (Hp). Like Hp, Hpr also binds hemoglobin (Hb) with high affinity, but it does not bind to...
8.
Laska M, Moeller J, Graversen J, Strobaek D, Blomster L, Christophersen P, et al.
Clin Immunol
. 2022 Jul;
242:109081.
PMID: 35905828
Peptides derived from retroviral envelope proteins have been shown to possess a wide range of immunosuppressive and anti-inflammatory activities. We have previously reported identification of such a peptide derived from...
9.
Indira Chandran V, Wernberg C, Lauridsen M, Skytthe M, Bendixen S, Larsen F, et al.
Hepatology
. 2022 Jun;
77(2):558-572.
PMID: 35712786
Background And Aims: Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid...
10.
Palarasah Y, Pham S, Gram J, Graversen J, Pilely K, Sidelmann J
Front Cardiovasc Med
. 2022 Jun;
9:873975.
PMID: 35669477
Objectives: The contact system consists of coagulation factor XII (FXII), prekallikrein, and H-kininogen (HK) and plays important roles in many diseases. Plasma kallikrein (PKa) cleaved HK (cHK) is a marker...