Jon R Lorsch
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Explore the profile of Jon R Lorsch including associated specialties, affiliations and a list of published articles.
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87
Citations
4125
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Recent Articles
1.
Lorsch J, Tabak L, Bertagnolli M
Elife
. 2024 Sep;
13.
PMID: 39254068
Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.
2.
Zhou F, Bocetti J, Hou M, Qin D, Hinnebusch A, Lorsch J
Elife
. 2024 Apr;
13.
PMID: 38573742
We have developed a deep sequencing-based approach, Rec-Seq, that allows simultaneous monitoring of ribosomal 48S preinitiation complex (PIC) formation on every mRNA in the translatome in an in vitro reconstituted...
3.
Bianchi D, Brennan P, Chiang M, Criswell L, DSouza R, Gibbons G, et al.
Nat Med
. 2024 Feb;
30(2):330-333.
PMID: 38374344
No abstract available.
4.
Zhou F, Bocetti J, Hou M, Qin D, Hinnebusch A, Lorsch J
bioRxiv
. 2023 Nov;
PMID: 37986768
We have developed a deep sequencing-based approach, Rec-Seq, that allows simultaneous monitoring of ribosomal 48S pre-initiation complex (PIC) formation on every mRNA in the translatome in an in vitro reconstituted...
5.
Gammie A, Dorsey T, Epou S, Miklos A, Lorsch J
ATS Sch
. 2022 Oct;
3(3):358-378.
PMID: 36312807
The National Institute of General Medical Sciences Medical Scientist Training Program (MSTP) has been successful in producing clinician-scientists, with a majority of graduates pursuing research-related careers. However, there are a...
6.
Bond M, Gammie A, Lorsch J
Mol Biol Cell
. 2020 Oct;
31(22):2409-2414.
PMID: 33054637
The National Institute of General Medical Sciences (NIGMS) at the U.S. National Institutes of Health (NIH) is committed to supporting the safety of the nation's biomedical research and training environments....
7.
Gulay S, Gupta N, Lorsch J, Hinnebusch A
Elife
. 2020 May;
9.
PMID: 32469309
Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eIF4F, enhance...
8.
Zhou F, Zhang H, Kulkarni S, Lorsch J, Hinnebusch A
RNA
. 2020 Jan;
26(4):419-438.
PMID: 31915290
The translation preinitiation complex (PIC) scans the mRNA for an AUG codon in a favorable context. Previous findings suggest that the factor eIF1 discriminates against non-AUG start codons by impeding...
9.
Kulkarni S, Zhou F, Sen N, Zhang H, Hinnebusch A, Lorsch J
BMC Biol
. 2019 Dec;
17(1):101.
PMID: 31810458
Background: Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as...
10.
Sen N, Gupta N, Archer S, Preiss T, Lorsch J, Hinnebusch A
Nucleic Acids Res
. 2019 Jul;
47(16):8785-8806.
PMID: 31299079
RNA structures that impede ribosome binding or subsequent scanning of the 5'-untranslated region (5'-UTR) for the AUG initiation codon reduce translation efficiency. Yeast DEAD-box RNA helicase Ded1 appears to promote...