Jon Pey
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Explore the profile of Jon Pey including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
203
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Recent Articles
1.
Antoranz A, Ortiz M, Pey J
BMC Bioinformatics
. 2022 Aug;
23(1):324.
PMID: 35933325
A gene is considered as essential when it is indispensable for cells to grow and replicate in a certain environment. However, gene essentiality is not a structural property but rather...
2.
Pey J, Jose-Eneriz E, Ochoa M, Apaolaza I, de Atauri P, Rubio A, et al.
Sci Rep
. 2017 Nov;
7(1):14358.
PMID: 29084986
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass,...
3.
Tobalina L, Pey J, Planes F
Bioinformatics
. 2016 May;
32(13):2001-7.
PMID: 27153694
Motivation: The concept of Minimal Cut Sets (MCSs) is used in metabolic network modeling to describe minimal groups of reactions or genes whose simultaneous deletion eliminates the capability of the...
4.
Tobalina L, Pey J, Rezola A, Planes F
PLoS One
. 2016 May;
11(5):e0154583.
PMID: 27145226
Motivation: Gene Essentiality Analysis based on Flux Balance Analysis (FBA-based GEA) is a promising tool for the identification of novel metabolic therapeutic targets in cancer. The reconstruction of cancer-specific metabolic...
5.
Tobalina L, Bargiela R, Pey J, Herbst F, Lores I, Rojo D, et al.
Bioinformatics
. 2015 Jan;
31(11):1771-9.
PMID: 25618865
Motivation: With the advent of meta-'omics' data, the use of metabolic networks for the functional analysis of microbial communities became possible. However, while network-based methods are widely developed for single...
6.
Pey J, Villar J, Tobalina L, Rezola A, Garcia J, Beasley J, et al.
Bioinformatics
. 2014 Nov;
31(6):897-904.
PMID: 25380956
Motivation: Elementary flux modes (EFMs) analysis constitutes a fundamental tool in systems biology. However, the efficient calculation of EFMs in genome-scale metabolic networks (GSMNs) is still a challenge. We present...
7.
Rezola A, Pey J, Rubio A, Planes F
PLoS One
. 2014 Aug;
9(8):e103998.
PMID: 25093336
Metabolism expresses the phenotype of living cells and understanding it is crucial for different applications in biotechnology and health. With the increasing availability of metabolomic, proteomic and, to a larger...
8.
Pey J, Planes F
Bioinformatics
. 2014 Apr;
30(15):2197-203.
PMID: 24728852
Motivation: The concept of Elementary Flux Mode (EFM) has been widely used for the past 20 years. However, its application to genome-scale metabolic networks (GSMNs) is still under development because...
9.
Rezola A, Pey J, Tobalina L, Rubio A, Beasley J, Planes F
Brief Bioinform
. 2014 Mar;
16(2):265-79.
PMID: 24626528
With the emergence of metabolic networks, novel mathematical pathway concepts were introduced in the past decade, aiming to go beyond canonical maps. However, the use of network-based pathways to interpret...
10.
Pey J, Valgepea K, Rubio A, Beasley J, Planes F
BMC Syst Biol
. 2013 Dec;
7:134.
PMID: 24314206
Background: The study of cellular metabolism in the context of high-throughput -omics data has allowed us to decipher novel mechanisms of importance in biotechnology and health. To continue with this...