John W M Creemers
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Explore the profile of John W M Creemers including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
1955
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Recent Articles
1.
Xu Y, Pepe D, Yao S, Boudhan L, Verbandt S, Pu T, et al.
J Cell Mol Med
. 2024 Jul;
28(14):e18441.
PMID: 39023696
Although leucine zipper tumour suppressor 1 (LZTS1) has been considered a potential tumour suppressor, accumulating evidence suggests that LZTS1 is highly expressed in many cancer types. To unravel the exact...
2.
He Z, IJpma A, Vreeken D, Heijsman D, Rosier K, Verhagen H, et al.
Cardiovasc Res
. 2024 Apr;
120(17):2278-2292.
PMID: 38636100
Aims: Aortic aneurysms (AA) frequently involve dysregulation of transforming growth factor β (TGF-β)-signalling in the aorta. Here, FURIN was tested as aneurysm predisposition gene given its role as proprotein convertase...
3.
Bhalla K, Rosier K, Monnens Y, Meulemans S, Vervoort E, Thorrez L, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Apr;
1870(5):167175.
PMID: 38626828
Loss of prolyl endopeptidase-like (PREPL) encoding a serine hydrolase with (thio)esterase activity leads to the recessive metabolic disorder Congenital Myasthenic Syndrome-22 (CMS22). It is characterized by severe neonatal hypotonia, feeding...
4.
Xu Y, He Z, Du J, Chen Z, Creemers J, Wang B, et al.
Int J Biol Sci
. 2023 Nov;
19(16):5120-5144.
PMID: 37928272
The dysfunction of immune cell development often impairs immunological homeostasis, thus causing various human diseases. Accumulating evidence shows that the development of different immune cells from hematopoietic stem cells are...
5.
Courbon G, Thomas J, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, et al.
Blood
. 2023 Apr;
142(1):106-118.
PMID: 37053547
Inflammation leads to functional iron deficiency by increasing the expression of the hepatic iron regulatory peptide hepcidin. Inflammation also stimulates fibroblast growth factor 23 (FGF23) production by increasing both Fgf23...
6.
Coppola I, Brouwers B, Walker L, Alar C, Meulemans S, White A, et al.
Mol Metab
. 2022 Nov;
66:101627.
PMID: 36374777
Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent...
7.
Liang Z, Zhang Z, Zhang Q, Dong X, Yang X, Zhang J, et al.
iScience
. 2022 Oct;
25(10):105233.
PMID: 36274943
The generation of mature T cells and establishment of central tolerance is predominantly orchestrated by thymic epithelial cells (TECs). Proprotein convertases are responsible for the proteolysis of proproteins into their...
8.
Descarpentrie J, Arauzo-Bravo M, He Z, Francois A, Gonzalez A, Garcia-Gallastegi P, et al.
Cancers (Basel)
. 2022 Mar;
14(5).
PMID: 35267511
Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem cells (CSCs) have been less widely...
9.
He Z, Khatib A, Creemers J
Oncogene
. 2022 Jan;
41(9):1252-1262.
PMID: 34997216
Furin is the first discovered proprotein convertase member and is present in almost all mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins, Furin expression and/or...
10.
Rosier K, McDevitt M, Smet J, Floyd B, Verschoore M, Marcaida M, et al.
iScience
. 2021 Dec;
24(12):103460.
PMID: 34888501
Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency. The pathophysiology of PREPL deficiency and the...