Sandra Meulemans
Overview
Explore the profile of Sandra Meulemans including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
485
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Monnens Y, Theodoropoulou A, Rosier K, Bhalla K, Mahy A, Vanhoutte R, et al.
JCI Insight
. 2024 Jul;
9(17).
PMID: 39078710
Congenital myasthenic syndrome-22 (CMS22, OMIM 616224) is a rare genetic disorder caused by deleterious genetic variation in the prolyl endopeptidase-like (PREPL) gene. Previous reports have described patients with deletions and...
2.
Bhalla K, Rosier K, Monnens Y, Meulemans S, Vervoort E, Thorrez L, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Apr;
1870(5):167175.
PMID: 38626828
Loss of prolyl endopeptidase-like (PREPL) encoding a serine hydrolase with (thio)esterase activity leads to the recessive metabolic disorder Congenital Myasthenic Syndrome-22 (CMS22). It is characterized by severe neonatal hypotonia, feeding...
3.
Coppola I, Brouwers B, Walker L, Alar C, Meulemans S, White A, et al.
Mol Metab
. 2022 Nov;
66:101627.
PMID: 36374777
Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent...
4.
Coppola I, Brouwers B, Meulemans S, Ramos-Molina B, Creemers J
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34198511
The insulin receptor (IR) is critically involved in maintaining glucose homeostasis. It undergoes proteolytic cleavage by proprotein convertases, which is an essential step for its activation. The importance of the...
5.
He Z, Thorrez L, Siegfried G, Meulemans S, Evrard S, Tejpar S, et al.
Oncogene
. 2020 Mar;
39(17):3571-3587.
PMID: 32139876
Mutations in KRAS and/or BRAF that activate the ERK kinase are frequently found in colorectal cancer (CRC) and drive resistance to targeted therapies. Therefore, the identification of therapeutic targets that...
6.
Regal L, Martensson E, Maystadt I, Voermans N, Lederer D, Burlina A, et al.
Genet Med
. 2017 Jul;
20(1):109-118.
PMID: 28726805
PurposePREPL deficiency causes neonatal hypotonia, ptosis, neonatal feeding difficulties, childhood obesity, xerostomia, and growth hormone deficiency. Different recessive contiguous gene deletion syndromes involving PREPL and a variable combination of SLC3A1...
7.
Declercq J, Ramos-Molina B, Sannerud R, Brouwers B, Pruniau V, Meulemans S, et al.
Eur J Cell Biol
. 2017 Apr;
96(5):432-439.
PMID: 28413120
Proprotein Convertase 7 (PC7) is a Furin-like endoprotease that cleaves precursor proteins at basic amino acids. PC7 is concentrated in the trans-Golgi network (TGN) but it shuttles between the plasma...
8.
Tuand K, Stijnen P, Volders K, Declercq J, Nuytens K, Meulemans S, et al.
PLoS One
. 2016 Mar;
11(3):e0151954.
PMID: 26999814
Background: Neurobeachin (NBEA) is an autism spectrum disorders (ASD) candidate gene. NBEA deficiency affects regulated secretion, receptor trafficking, synaptic architecture and protein kinase A (PKA)-mediated phosphorylation. NBEA is a large...
9.
Declercq J, Brouwers B, Pruniau V, Stijnen P, de Faudeur G, Tuand K, et al.
PLoS One
. 2015 Aug;
10(8):e0135502.
PMID: 26275221
The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been suggested, a comprehensive explanation is still lacking. In...
10.
Declercq J, Brouwers B, Pruniau V, Stijnen P, Tuand K, Meulemans S, et al.
Biomed Res Int
. 2015 Jul;
2015:148651.
PMID: 26167473
Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors, metalloproteases, and extracellular matrix proteins. Therefore, it has been suggested that...