John W Harney
Overview
Explore the profile of John W Harney including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
44
Citations
2367
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bartha T, Kim S, Salvatore D, Gereben B, Tu H, Harney J, et al.
Endocrinology
. 2017 Feb;
141(1):229-237.
PMID: 28200904
No abstract available.
2.
Luongo C, Martin C, Vella K, Marsili A, Ambrosio R, Dentice M, et al.
Endocrinology
. 2014 Dec;
156(2):745-54.
PMID: 25456070
The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T4. We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre...
3.
Wittmann G, Harney J, Singru P, Nouriel S, Larsen P, Lechan R
Endocrinology
. 2014 Mar;
155(5):2009-19.
PMID: 24601886
Thyroid hormone regulates immune functions and has antiinflammatory effects. In promoter assays, the thyroid hormone-activating enzyme, type 2 deiodinase (D2), is highly inducible by the inflammatory transcription factor nuclear factor-κ...
4.
Zhu B, Shrivastava A, Luongo C, Chen T, Harney J, Marsili A, et al.
J Endocrinol
. 2012 May;
214(1):87-94.
PMID: 22544951
Previously, it was shown that the type 1 deiodinase (D1) is subject to substrate-dependent inactivation that is blocked by pretreatment with the inhibitor of D1 catalysis, propylthiouracil (PTU). Using HepG2...
5.
Marsili A, Sanchez E, Singru P, Harney J, Zavacki A, Lechan R, et al.
J Endocrinol
. 2011 Jul;
211(1):73-8.
PMID: 21788297
Suppression of TSH release from the hypothyroid thyrotrophs is one of the most rapid effects of 3,3',5'-triiodothyronine (T(3)) or thyroxine (T(4)). It is initiated within an hour, precedes the decrease...
6.
Marsili A, Tang D, Harney J, Singh P, Zavacki A, Dentice M, et al.
Am J Physiol Endocrinol Metab
. 2011 Jul;
301(5):E818-24.
PMID: 21771965
The FoxO3-dependent increase in type II deiodinase (D2), which converts the prohormone thyroxine (T(4)) to 3,5,3'-triiodothyronine (T(3)), is required for normal mouse skeletal muscle differentiation and regeneration. This implies a...
7.
Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford E, et al.
PLoS One
. 2011 Jun;
6(6):e20832.
PMID: 21698184
Background: The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and...
8.
Marsili A, Ramadan W, Harney J, Mulcahey M, Castroneves L, Goemann I, et al.
Endocrinology
. 2010 Oct;
151(12):5952-60.
PMID: 20881246
Because of its large mass, relatively high metabolic activity and responsiveness to thyroid hormone, skeletal muscle contributes significantly to energy expenditure. Despite the presence of mRNA encoding the type 2...
9.
Goemann I, Gereben B, Harney J, Zhu B, Maia A, Larsen P
Endocrinology
. 2009 Dec;
151(2):821-9.
PMID: 19966180
T(4) must be activated by its monodeiodination to T(3) by type 1 or 2 iodothyronine deiodinase (D1 and D2). Recent studies show that despite an approximately 2000-fold higher Michaelis constant...
10.
Aerts G, Arrojo E Drigo R, Van Herck S, Sammels E, Mirebeau-Prunier D, Gereben B, et al.
Endocrinology
. 2009 Oct;
150(11):5171-80.
PMID: 19819956
The type 3 iodothyronine deiodinase (D3) is the primary deiodinase that inactivates thyroid hormone. Immunoprecipitation of D3, followed by fluorescent two-dimensional difference gel electrophoresis and mass spectrometry, identified peroxiredoxin 3...