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John V Tsimikas

Explore the profile of John V Tsimikas including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 24
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Recent Articles
1.
Bantis L, Young K, Tsimikas J, Mosier B, Gajewski B, Yeatts S, et al.
Res Methods Med Health Sci . 2023 Apr; 4(1):34-48. PMID: 37009524
Studies that investigate the performance of prognostic and predictive biomarkers are commonplace in medicine. Evaluating the performance of biomarkers is challenging in traumatic brain injury (TBI) and other conditions when...
2.
Bantis L, Tsimikas J
Stat Med . 2022 May; 41(18):3527-3546. PMID: 35543227
Pancreatic ductal adenocarcinoma (PDAC) is the most deadly cancer and currently there is strong clinical interest in novel biomarkers that contribute to its early detection. Assessing appropriately the accuracy of...
3.
Bantis L, Tsimikas J, Chambers G, Capello M, Hanash S, Feng Z
Stat Med . 2021 Feb; 40(7):1767-1789. PMID: 33530129
During the early stage of biomarker discovery, high throughput technologies allow for simultaneous input of thousands of biomarkers that attempt to discriminate between healthy and diseased subjects. In such cases,...
4.
Bantis L, Tsimikas J, Georgiou S
Comput Methods Programs Biomed . 2020 Feb; 190:105357. PMID: 32036203
Background And Objectives: In survival analysis both the Kaplan-Meier estimate and the Cox model enjoy a broad acceptance. We present an improved spline-based survival estimate and offer a fully automated...
5.
Bantis L, Yan Q, Tsimikas J, Feng Z
Stat Med . 2017 Aug; 36(24):3830-3843. PMID: 28786136
Protein biomarkers found in plasma are commonly used for cancer screening and early detection. Measurements obtained by such markers are often based on different assays that may not support detection...
6.
Bantis L, Tsimikas J, Georgiou S
Biom J . 2013 Apr; 55(5):719-40. PMID: 23553499
The use of ROC curves in evaluating a continuous or ordinal biomarker for the discrimination of two populations is commonplace. However, in many settings, marker measurements above or below a...
7.
Bantis L, Tsimikas J, Georgiou S
Lifetime Data Anal . 2012 Mar; 18(3):364-96. PMID: 22399231
In this paper we explore the estimation of survival probabilities via a smoothed version of the survival function, in the presence of censoring. We investigate the fit of a natural...
8.
Tsimikas J, Bosch R, Coull B, El Barmi H
Biometrics . 2002 Dec; 58(4):946-56. PMID: 12495149
We consider profile-likelihood inference based on the multinomial distribution for assessing the accuracy of a diagnostic test. The methods apply to ordinal rating data when accuracy is assessed using the...