John Tengbom
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Explore the profile of John Tengbom including associated specialties, affiliations and a list of published articles.
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13
Citations
70
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Recent Articles
1.
Collado A, Jiao T, Kontidou E, Carvalho L, Chernogubova E, Yang J, et al.
Br J Pharmacol
. 2024 Oct;
182(2):417-431.
PMID: 39402703
Background And Purpose: MicroRNA (miR)-210 function in endothelial cells and its role in diabetes-associated endothelial dysfunction are not fully understood. We aimed to characterize the miR-210 function in endothelial cells...
2.
Tengbom J, Humoud R, Kontidou E, Jiao T, Yang J, Hedin U, et al.
Am J Physiol Heart Circ Physiol
. 2024 Oct;
327(6):H1431-H1441.
PMID: 39392478
Endothelial dysfunction is an early consequence of vascular inflammation and a driver of coronary atherosclerotic disease leading to myocardial infarction. The red blood cells (RBCs) mediate endothelial dysfunction in patients...
3.
Tengbom J, Kontidou E, Collado A, Yang J, Alvarsson M, Brinck J, et al.
Clin Sci (Lond)
. 2024 Jul;
138(15):975-985.
PMID: 39037711
The mechanisms underlying endothelial dysfunction in Type 1 and Type 2 diabetes (T1DM and T2DM) are unresolved. The red blood cells (RBCs) with increased arginase activity induce endothelial dysfunction in...
4.
Jiao T, Collado A, Mahdi A, Tengbom J, Tratsiakovich Y, Milne G, et al.
JACC Basic Transl Sci
. 2023 Sep;
8(8):907-918.
PMID: 37719424
Reduced nitric oxide (NO) bioactivity in red blood cells (RBCs) is critical for augmented myocardial ischemia-reperfusion injury in type 2 diabetes. This study identified the nature of "NO bioactivity" by...
5.
Yang J, Sundqvist M, Zheng X, Jiao T, Collado A, Tratsiakovich Y, et al.
J Clin Invest
. 2023 Sep;
133(17).
PMID: 37655658
Red blood cells (RBCs) mediate cardioprotection via nitric oxide-like bioactivity, but the signaling and the identity of any mediator released by the RBCs remains unknown. We investigated whether RBCs exposed...
6.
Mahdi A, Wodaje T, Kovamees O, Tengbom J, Zhao A, Jiao T, et al.
J Intern Med
. 2022 Nov;
293(2):228-245.
PMID: 36324273
Background: Patients with familial hypercholesterolemia (FH) display high levels of low-density lipoprotein cholesterol (LDL-c), endothelial dysfunction, and increased risk of premature atherosclerosis. We have previously shown that red blood cells...
7.
Jiao T, Collado A, Mahdi A, Jurga J, Tengbom J, Saleh N, et al.
Basic Res Cardiol
. 2022 Sep;
117(1):46.
PMID: 36112326
Red blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. It remains unknown whether such beneficial effects...
8.
Collado A, Gan L, Tengbom J, Kontidou E, Pernow J, Zhou Z
J Physiol
. 2022 Sep;
601(22):4989-5009.
PMID: 36094621
Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, have recently received attention as essential mechanisms for cell-to-cell communication in cardiovascular disease. EVs can be released from different types of...
9.
Mahdi A, Collado A, Tengbom J, Jiao T, Wodaje T, Johansson N, et al.
JACC Basic Transl Sci
. 2022 Feb;
7(3):193-204.
PMID: 35194565
Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of...
10.
Tengbom J, Cederstrom S, Verouhis D, Bohm F, Eriksson P, Folkersen L, et al.
J Intern Med
. 2021 Jul;
290(5):1061-1070.
PMID: 34237174
Background: The mechanisms underlying rupture of a coronary atherosclerotic plaque and development of myocardial ischemia-reperfusion injury in ST-elevation myocardial infarction (STEMI) remain unresolved. Increased arginase 1 activity leads to reduced...