John Steven
Overview
Explore the profile of John Steven including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
275
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0
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Recent Articles
1.
Leach A, Finnegan M, Machado M, Ferguson L, Steven J, Smyth P, et al.
J Mater Chem B
. 2023 Apr;
11(19):4181-4190.
PMID: 37092346
Actively targeted drug loaded nanoparticles represent an exciting new form of therapeutics for cancer and other diseases. These formulations are complex and in order to realize their ultimate potential, optimization...
2.
Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature
Leach A, Smyth P, Ferguson L, Steven J, Greene M, Branco C, et al.
Nanoscale
. 2020 Jul;
12(27):14751-14763.
PMID: 32626858
Whilst there is an extensive body of preclinical nanomedicine research, translation to clinical settings has been slow. Here we present a novel approach to the targeted nanoparticle (NP) concept: utilizing...
3.
Steven J, Ubah O, Buschhaus M, Kovaleva M, Ferguson L, Porter A, et al.
Methods Mol Biol
. 2019 Oct;
2070:115-142.
PMID: 31625093
VNAR domains are the binding regions of new antigen receptor proteins (IgNAR) which are unique to sharks, skates, and rays (Elasmobranchii). Individual VNAR domains can bind antigens independently and are...
4.
Pepple K, Wilson L, Van Gelder R, Kovaleva M, Ubah O, Steven J, et al.
Transl Vis Sci Technol
. 2019 Oct;
8(5):11.
PMID: 31588375
Purpose: We assess the efficacy of two next-generation biologic therapies in treating experimental autoimmune uveitis. Methods: Variable binding domains from shark immunoglobulin novel antigen receptors (VNARs) were fused with a...
5.
Nogueira J, Greene M, Richards D, Furby A, Steven J, Porter A, et al.
Chem Commun (Camb)
. 2019 Jun;
55(53):7671-7674.
PMID: 31204425
Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using...
6.
Ubah O, Steven J, Porter A, Barelle C
Front Immunol
. 2019 Apr;
10:526.
PMID: 30967865
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases. Targeting TNF-α as a treatment modality...
7.
ODwyer R, Kovaleva M, Zhang J, Steven J, Cummins E, Luxenberg D, et al.
J Immunol Res
. 2018 Nov;
2018:4089459.
PMID: 30417018
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The...
8.
Ubah O, Buschhaus M, Ferguson L, Kovaleva M, Steven J, Porter A, et al.
Biochem Soc Trans
. 2018 Nov;
46(6):1559-1565.
PMID: 30381336
Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of...
9.
Ubah O, Steven J, Kovaleva M, Ferguson L, Barelle C, Porter A, et al.
Front Immunol
. 2018 Jan;
8:1780.
PMID: 29312310
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite...
10.
Steven J, Muller M, Carvalho M, Ubah O, Kovaleva M, Donohoe G, et al.
Front Immunol
. 2017 Nov;
8:1361.
PMID: 29109729
Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy is often used to reduce undesirable...