John R Reddan
Overview
Explore the profile of John R Reddan including associated specialties, affiliations and a list of published articles.
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11
Citations
199
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Recent Articles
1.
Liu H, Smith A, Lott M, Bao Y, Bowater R, Reddan J, et al.
Invest Ophthalmol Vis Sci
. 2013 Jul;
54(8):5236-48.
PMID: 23812493
Purpose: Protecting the lens against oxidative stress is of great importance in delaying the onset of cataract. Isothiocyanates, such as sulforaphane (SFN), are proposed to provide cytoprotection against oxidative stress....
2.
Wang L, Eldred J, Sidaway P, Sanderson J, Smith A, Bowater R, et al.
Mech Ageing Dev
. 2012 Oct;
133(11-12):665-74.
PMID: 23041531
Stimulation of sigma-1 receptors is reported to protect against oxidative stress. The present study uses cells and tissue from the human lens to elucidate the relationship between the sigma 1...
3.
Eldred J, Hodgkinson L, Dawes L, Reddan J, Edwards D, Wormstone I
Invest Ophthalmol Vis Sci
. 2012 May;
53(7):4085-98.
PMID: 22618590
Purpose: The fibrotic lens disorder posterior capsule opacification (PCO) develops in millions of patients following cataract surgery. PCO characteristics are extensive extracellular matrix (ECM) production and contraction of the posterior...
4.
Dawes L, Sleeman M, Anderson I, Reddan J, Wormstone I
Invest Ophthalmol Vis Sci
. 2009 Jun;
50(11):5318-27.
PMID: 19516008
Purpose: Transforming growth factor (TGF)-beta can mediate fibrotic responses via Smad4-dependent and -independent signaling pathways. TGFbeta-induced transdifferentiation of lens epithelial cells to myofibroblasts and matrix contraction contribute to posterior capsule...
5.
Nathu Z, Dwivedi D, Reddan J, Sheardown H, Margetts P, West-Mays J
Exp Eye Res
. 2008 Sep;
88(2):323-30.
PMID: 18809398
Transforming growth factor beta (TGFbeta) has been known to play a role in anterior subcapsular cataract (ASC) formation and posterior capsule opacification (PCO), both of which are fibrotic pathologies of...
6.
Dawes L, Eldred J, Anderson I, Sleeman M, Reddan J, Duncan G, et al.
Invest Ophthalmol Vis Sci
. 2008 Feb;
49(2):650-61.
PMID: 18235011
Purpose: Transforming growth factor (TGF)-beta is a potent inducer of both transdifferentiation and contraction, which are regarded as critical processes that underpin tissue fibrosis. Consequently, transdifferentiation is believed to drive...
7.
Zhang H, Duncan G, Wang L, Liu P, Cui H, Reddan J, et al.
Exp Eye Res
. 2007 Oct;
85(6):825-35.
PMID: 17963750
Identification of novel agents to eradicate the residual lens cell population following cataract surgery provides one mode of preventing PCO formation. The present study investigated the biological mechanism of As(2)O(3)...
8.
Dawes L, Angell H, Sleeman M, Reddan J, Wormstone I
Exp Eye Res
. 2007 Mar;
84(5):1009-12.
PMID: 17328892
No abstract available.
9.
Obrenovich M, Fan X, Satake M, Jarvis S, Reneker L, Reddan J, et al.
Mol Cell Biochem
. 2006 Aug;
293(1-2):53-62.
PMID: 16933033
Vitamin C is a major antioxidant and UV absorbent in the human lens. In the rodent lens, the levels are very low for unknown reasons. Searching for clues to explain...
10.
Wang L, Wormstone I, Reddan J, Duncan G
Exp Eye Res
. 2005 Jun;
80(6):885-95.
PMID: 15939046
In the human lens, stimulation of tyrosine-kinase coupled growth factor receptors such as epidermal growth factor receptor (EGFR) can induce calcium release from endoplasmic reticulum (ER) stores. The present study...