I Michael Wormstone
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Explore the profile of I Michael Wormstone including associated specialties, affiliations and a list of published articles.
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36
Citations
778
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Recent Articles
1.
Cooksley G, Nam M, Nahomi R, Rankenberg J, Smith A, Wormstone Y, et al.
Aging Cell
. 2024 Oct;
23(10):e14249.
PMID: 39384405
Posterior capsule opacification (PCO) is a common complication after cataract surgery. Residual lens epithelial cells (LECs) on the anterior lens capsule, after cataract surgery, migrate to the posterior lens capsule...
2.
Huynh T, Bowater R, Bernuzzi F, Saha S, Wormstone I
Invest Ophthalmol Vis Sci
. 2021 Dec;
62(15):2.
PMID: 34854886
Purpose: Sulforaphane (SFN) is a therapeutic phytochemical agent for many health conditions. SFN-induced cytotoxicity is shown to have promise in preventing posterior capsule opacification (PCO). In the current study, we...
3.
Huangfu J, Hao C, Wei Z, Wormstone I, Yan H, Fan X
Cell Death Dis
. 2021 Apr;
12(4):386.
PMID: 33837174
The present study aims to understand the mechanism of the lens epithelial cell's strong anti-apoptotic capacity and survival in the mature human lens that, on the one hand, maintains lens...
4.
Wormstone I, Damm N, Kelp M, Eldred J
Exp Eye Res
. 2021 Feb;
205:108487.
PMID: 33571531
Intraocular lenses (IOLs) are implanted during cataract surgery. For optimum results, stable positioning of the IOL in the capsular bag is important. Wound-healing events following cataract surgery lead to modification...
5.
Nam M, Smith A, Pantcheva M, Park K, Brzezinski J, Galligan J, et al.
Biochem J
. 2019 Dec;
477(1):75-97.
PMID: 31815277
Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth...
6.
Wormstone I
Eye (Lond)
. 2019 Nov;
34(2):225-231.
PMID: 31745327
Posterior capsule opacification (PCO) is the most common complication following cataract surgery and affects millions of patients. PCO is a consequence of surgical injury promoting a wound-healing response. Following surgery,...
7.
Smith A, Eldred J, Wormstone I
Invest Ophthalmol Vis Sci
. 2019 Sep;
60(12):3863-3877.
PMID: 31529119
Purpose: Posterior capsule opacification (PCO) is a common complication of cataract surgery. In addition to improved surgical methods and IOL designs, it is likely additional agents will be needed to...
8.
Liu H, Li L, Wormstone I, Qiao C, Zhang C, Liu P, et al.
JAMA Ophthalmol
. 2019 Sep;
137(12):1353-1360.
PMID: 31513266
Importance: A deep learning system (DLS) that could automatically detect glaucomatous optic neuropathy (GON) with high sensitivity and specificity could expedite screening for GON. Objective: To establish a DLS for...
9.
Eldred J, Zheng J, Chen S, Wormstone I
Invest Ophthalmol Vis Sci
. 2019 Jan;
60(1):113-122.
PMID: 30629726
Purpose: To develop a culture regime for the in vitro human lens capsular bag model that better reflects clinical events following cataract surgery and to use this refined model to...
10.
Liu H, Smith A, Ball S, Bao Y, Bowater R, Wang N, et al.
J Mol Med (Berl)
. 2017 Jan;
95(5):553-564.
PMID: 28083623
Key Message: SFN reduces lens epithelial cell growth, migration, and viability. SFN can promote ER stress and autophagy in lens cells. SFN promotes MAPK signaling, and inhibition of MEK can...