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John R Raymond

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Articles 35
Citations 664
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Recent Articles
1.
Raymond J
WMJ . 2021 Jan; 119(4):229-239. PMID: 33428832
Background: Despite a rapidly growing and evolving literature, there continues to be a vigorous public debate about whether the community use of face coverings can mitigate the spread of COVID-19...
2.
Patrick K, Radke J, Raymond J, Koller L, Nguyen L, Rodriguez W, et al.
Pharmacotherapy . 2018 Oct; 39(6):677-688. PMID: 30351459
In 2000, the first biphasic modified-release (MR) formulation of methylphenidate (MPH) was approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). An immediate-release (IR) MPH pulse (22% of the dose) facilitates...
3.
Copik A, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, et al.
PLoS One . 2015 Jan; 10(1):e0115701. PMID: 25606852
The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to...
4.
Velez J, Ierardi J, Bland A, Morinelli T, Arthur J, Raymond J, et al.
Am J Physiol Renal Physiol . 2012 Mar; 302(12):F1583-94. PMID: 22461301
The intraglomerular renin-angiotensin system (RAS) is linked to the pathogenesis of progressive glomerular diseases. Glomerular podocytes and mesangial cells play distinct roles in the metabolism of angiotensin (ANG) peptides. However,...
5.
Baldys A, Raymond J
J Biol Chem . 2011 Apr; 286(28):24656-65. PMID: 21464131
The 5-hydroxytryptamine 2A receptor (5-HT(2A)R) undergoes constitutive and agonist-dependent internalization. Despite many advances in our understanding of G protein-coupled receptor trafficking, the exact mechanism of endocytic sorting of G protein-coupled...
6.
Bunni M, Kramarenko I, Walker L, Raymond J, Garnovskaya M
Am J Physiol Cell Physiol . 2010 Dec; 300(3):C647-56. PMID: 21148411
Angiotensin II (AII) binds to G protein-coupled receptor AT(1) and stimulates extracellular signal-regulated kinase (ERK), leading to vascular smooth muscle cells (VSMC) proliferation. Proliferation of mammalian cells is tightly regulated...
7.
Tholanikunnel B, Joseph K, Kandasamy K, Baldys A, Raymond J, Luttrell L, et al.
J Biol Chem . 2010 Aug; 285(44):33816-25. PMID: 20739277
β(2)-adrenergic receptors (β(2)-AR) are low abundance, integral membrane proteins that mediate the effects of catecholamines at the cell surface. Whereas the processes governing desensitization of activated β(2)-ARs and their subsequent...
8.
Dey M, Baldys A, Sumter D, Gooz P, Luttrell L, Raymond J, et al.
J Pharmacol Exp Ther . 2010 Jun; 334(3):775-83. PMID: 20566668
Recent data show that increases in bradykinin (BK) concentration contribute to the beneficial effects of angiotensin-converting enzyme inhibitor (ACEI) treatment in chronic kidney disease. However, the possible role of BK...
9.
Kramarenko I, Bunni M, Raymond J, Garnovskaya M
Mol Pharmacol . 2010 Apr; 78(1):126-34. PMID: 20385709
We have shown previously that the vasoactive peptide bradykinin (BK) stimulates proliferation of a cultured murine cell model of the inner medullary collecting duct (mIMCD-3 cells) via transactivation of epidermal...
10.
Baldys A, Raymond J
Biochemistry . 2009 Aug; 48(40):9321-3. PMID: 19673488
The molecular mechanisms of EGFR vesicular trafficking to lysosomes have recently received considerable attention. It is now clear that endosomal sorting complexes required for transport (ESCRTs) are critical for EGFR...