John R Grider
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Explore the profile of John R Grider including associated specialties, affiliations and a list of published articles.
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76
Citations
1680
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Recent Articles
1.
Ziolkowska E, Jansen M, Williams L, Wang S, Eultgen E, Takahashi K, et al.
Sci Transl Med
. 2025 Jan;
17(781):eadj1445.
PMID: 39813314
Children with neurodegenerative disease often have debilitating gastrointestinal symptoms. We hypothesized that this may be due at least in part to underappreciated degeneration of neurons in the enteric nervous system...
2.
Mazzotta E, Grants I, Villalobos-Hernandez E, Chaudhuri S, McClain J, Seguella L, et al.
Br J Pharmacol
. 2023 May;
180(19):2550-2576.
PMID: 37198101
Background And Purpose: ET-1 signalling modulates intestinal motility and inflammation, but the role of ET-1/ET receptor signalling is poorly understood. Enteric glia modulate normal motility and inflammation. We investigated whether...
3.
Singh K, Randhwa G, Salloum F, Grider J, Murthy K
Neurogastroenterol Motil
. 2020 Aug;
33(2):e13968.
PMID: 32789934
Background: Duchenne muscular dystrophy (DMD) is characterized by the lack of dystrophin in skeletal, cardiac, and smooth muscle. Slow colonic transit and constipation are common in DMD patients and animal...
4.
Rhyu M, Song A, Kim E, Son H, Kim Y, Mummalaneni S, et al.
Nutrients
. 2020 Apr;
12(4).
PMID: 32344605
Kokumi taste substances exemplified by γ-glutamyl peptides and Maillard Peptides modulate salt and umami tastes. However, the underlying mechanism for their action has not been delineated. Here, we investigated the...
5.
Li C, Grider J, Murthy K, Bohl J, Rivet E, Wieghard N, et al.
Inflamm Bowel Dis
. 2020 Feb;
26(6):809-819.
PMID: 32031621
Background: Endoplasmic reticulum (ER) stress is an essential response of epithelial and immune cells to inflammation in Crohn's disease. The presence and mechanisms that might regulate the ER stress response...
6.
Crowe M, Wang H, Blakeney B, Mahavadi S, Singh K, Murthy K, et al.
Neurogastroenterol Motil
. 2019 Nov;
32(2):e13737.
PMID: 31721379
Background: l-amino acids, such as monosodium glutamate (MSG), activate the umami receptor T1R1/T1R3. We previously showed increased peristalsis in response to activation of T1R1/T1R3 by MSG in mouse colon. However,...
7.
Wang H, Murthy K, Grider J
Cell Tissue Res
. 2019 Aug;
378(3):471-483.
PMID: 31410629
Regulation of gut function depends on the detection and response to luminal contents. Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1...
8.
Mahavadi S, Nalli A, Wang H, Kendig D, Crowe M, Lyall V, et al.
PLoS One
. 2018 Dec;
13(12):e0209359.
PMID: 30571746
In gastrointestinal smooth muscle, acetylcholine induced muscle contraction is biphasic, initial peak followed by sustained contraction. Contraction is regulated by phosphorylation of 20 kDa myosin light chain (MLC) at Ser19,...
9.
Blakeney B, Crowe M, Mahavadi S, Murthy K, Grider J
Dig Dis Sci
. 2018 Dec;
64(5):1171-1181.
PMID: 30560338
Background: Isovaleric acid (IVA) is a 5-carbon branched-chain fatty acid present in fermented foods and produced in the colon by bacterial fermentation of leucine. We previously reported that the shorter,...
10.
May A, Crowe M, Blakeney B, Mahavadi S, Wang H, Grider J, et al.
Peptides
. 2018 Dec;
112:48-55.
PMID: 30508636
The insulinotropic effects of the incretin hormone, glucagon-like peptide-1 (GLP-1) are mediated via GLP-1 receptors (GLP-1R) present on pancreatic β cells. GLP-1 causes a decrease in the motility of stomach...