John P Kowalski
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Explore the profile of John P Kowalski including associated specialties, affiliations and a list of published articles.
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16
Citations
185
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Recent Articles
1.
Hicken E, Brown K, Dwulet N, Gaudino J, Hansen E, Hartley D, et al.
J Med Chem
. 2024 May;
67(11):9759-9771.
PMID: 38820338
HER2 overexpression and amplification have been identified as oncogenic drivers, and the development of therapies to treat tumors harboring these markers has received considerable attention. Activation of HER2 signaling and...
2.
Kowalski J, Rettie A
Drug Metab Dispos
. 2024 Apr;
52(6):498-507.
PMID: 38604728
Cytochrome P450 (CYP)4Z1, a highly expressed gene in breast cancer, was one of the last CYPs to be identified in the human genome, some 20 years ago. CYP4 enzymes typically...
3.
Pelletier R, Rettie A, Kowalski J
J Chromatogr B Analyt Technol Biomed Life Sci
. 2023 Nov;
1231:123921.
PMID: 37956555
Heme B is a critical prosthetic group for the function of numerous proteins including the cytochrome P450 (CYP) family of enzymes. CYP enzymes are involved in the metabolism of endogenous...
4.
Amorosi C, Chiasson M, McDonald M, Wong L, Sitko K, Boyle G, et al.
Am J Hum Genet
. 2021 Jul;
108(9):1735-1751.
PMID: 34314704
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular,...
5.
Kowalski J, Pelletier R, McDonald M, Kelly E, Rettie A
Xenobiotica
. 2021 May;
51(8):901-915.
PMID: 33993844
8-[(1H-1,2,3-benzotriazol-1-yl)amino]octanoic acid (8-BOA) was recently identified as a selective and potent mechanism-based inactivator (MBI) of breast cancer-associated CYP4Z1 and exhibited favourable inhibitory activity thus meriting characterization.The pharmacokinetics and metabolism of...
6.
McDonald M, Henderson L, Ray S, Yeung C, Johnson A, Kowalski J, et al.
J Pharmacol Exp Ther
. 2020 May;
374(2):233-240.
PMID: 32423989
CYP2C9 is a major form of human liver cytochrome P450 that is responsible for the oxidative metabolism of several widely used low-therapeutic index drugs, including ()-warfarin and phenytoin. In a...
7.
Kowalski J, McDonald M, Pelletier R, Hanenberg H, Wiek C, Rettie A
J Med Chem
. 2020 Apr;
63(9):4824-4836.
PMID: 32302132
Mammary-tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for its potential role in breast cancer progression. CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeicosatrienoic acid (14,15-EET), a metabolite known to...
8.
Thesseling F, Hutter M, Wiek C, Kowalski J, Rettie A, Girhard M
Arch Biochem Biophys
. 2019 Dec;
679:108216.
PMID: 31801692
CYP4B1 is an enigmatic mammalian cytochrome P450 monooxygenase acting at the interface between xenobiotic and endobiotic metabolism. A prominent CYP4B1 substrate is the furan pro-toxin 4-ipomeanol (IPO). Our recent investigation...
9.
Kowalski J, McDonald M, Whittington D, Guttman M, Scian M, Girhard M, et al.
Chem Res Toxicol
. 2019 Dec;
32(12):2488-2498.
PMID: 31799839
Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that...
10.
Teitelbaum A, McDonald M, Kowalski J, Parkinson O, Scian M, Whittington D, et al.
J Pharmacol Exp Ther
. 2018 Nov;
368(2):308-316.
PMID: 30409834
A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition...