John N Snouwaert
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Explore the profile of John N Snouwaert including associated specialties, affiliations and a list of published articles.
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20
Citations
639
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Recent Articles
1.
Koller B, Nguyen M, Snouwaert J, Gabel C, Ting J
Cell Rep
. 2024 Mar;
43(3):113852.
PMID: 38427558
The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1β, IL-18, and gasdermin-D in myeloid cells. However, research on species-specific NLRP3's physiological impact is limited. We...
2.
Smolak P, Nguyen M, Diamond C, Wescott H, Doedens J, Schooley K, et al.
J Pharmacol Exp Ther
. 2024 Jan;
388(3):798-812.
PMID: 38253384
The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is a central regulator of innate immunity, essential for processing and release of interleukin-1 and pyroptotic cell death. As endogenous NLRP3...
3.
Snouwaert J, Jania L, Nguyen T, Martinez D, Schafer A, Catanzaro N, et al.
PLoS Pathog
. 2023 Feb;
19(2):e1011168.
PMID: 36812267
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which...
4.
Matschiner G, Fitzgerald M, Moebius U, Hohlbaum A, Gille H, Jensen K, et al.
J Allergy Clin Immunol
. 2023 Jan;
151(4):966-975.
PMID: 36592703
Background: Type 2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle, and immunocytes in the respiratory mucosa,...
5.
Perryman A, Speen A, Kim H, Hoffman J, Clapp P, Rivera Martin W, et al.
Am J Respir Cell Mol Biol
. 2021 Jun;
65(5):500-512.
PMID: 34126877
Ozone (O) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol A...
6.
Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, et al.
Nat Commun
. 2021 May;
12(1):2574.
PMID: 33976140
Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness (AHR), mucus hypersecretion and eosinophilia. Approved therapeutic monoclonal antibodies...
7.
Koller B, Snouwaert J, Douillet C, Jania L, El-Masri H, Thomas D, et al.
Environ Health Perspect
. 2020 Aug;
128(8):87003.
PMID: 32779937
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced diseases. Mechanisms...
8.
Behrens K, Jania L, Snouwaert J, Nguyen M, Moy S, Tikunov A, et al.
PLoS One
. 2019 Nov;
14(11):e0225449.
PMID: 31747445
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which...
9.
Snouwaert J, Church R, Jania L, Nguyen M, Wheeler M, Saintsing A, et al.
Cell Rep
. 2018 Aug;
24(5):1254-1265.
PMID: 30067980
Lysosomes play a critical role in maintenance of the integrity of neuronal function, and mutations in genes that contribute to lysosome formation, transport, and activity are associated with neurodegenerative disorders....
10.
Snouwaert J, Nguyen M, Repenning P, Dye R, Livingston E, Kovarova M, et al.
Cell Rep
. 2016 Dec;
17(11):3077-3088.
PMID: 27974218
The NLRP3 inflammasome plays a critical role in host defense by facilitating caspase I activation and maturation of IL-1β and IL-18, whereas dysregulation of inflammasome activity results in autoinflammatory disease....