John N Snouwaert
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Explore the profile of John N Snouwaert including associated specialties, affiliations and a list of published articles.
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20
Citations
639
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Recent Articles
11.
Fay M, Nguyen M, Snouwaert J, Dye R, Grant D, Bodnar W, et al.
Drug Metab Dispos
. 2015 Sep;
43(12):1838-46.
PMID: 26354949
UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased...
12.
Xiang Z, Snouwaert J, Kovarova M, Nguyen M, Repenning P, Latour A, et al.
Drug Metab Dispos
. 2014 Mar;
42(6):1074-83.
PMID: 24658454
Glutathione S-transferases (GSTs) form a superfamily defined by their ability to catalyze the conjugation of glutathione with electrophilic substrates. These enzymes are proposed to play a critical role in protection...
13.
Sparks M, Makhanova N, Griffiths R, Snouwaert J, Koller B, Coffman T
Hypertension
. 2012 Nov;
61(1):166-73.
PMID: 23150508
The prostanoid thromboxane A2 has been implicated to contribute to the pathogenesis of many cardiovascular diseases, including hypertension. To study the role of vascular thromboxane-prostanoid (TP) receptors in blood pressure...
14.
Kovarova M, Hesker P, Jania L, Nguyen M, Snouwaert J, Xiang Z, et al.
J Immunol
. 2012 Jul;
189(4):2006-16.
PMID: 22753929
Acute inflammation in response to both exogenous and endogenous danger signals can lead to the assembly of cytoplasmic inflammasomes that stimulate the activation of caspase-1. Subsequently, caspase-1 facilitates the maturation...
15.
Cyphert J, Allen I, Church R, Latour A, Snouwaert J, Coffman T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2011 Oct;
302(1):L140-51.
PMID: 21984570
Actions of thromboxane (TXA(2)) to alter airway resistance were first identified over 25 years ago. However, the mechanism underlying this physiological response has remained largely undefined. Here we address this...
16.
Gurley S, Riquier-Brison A, Schnermann J, Sparks M, Allen A, Haase V, et al.
Cell Metab
. 2011 Apr;
13(4):469-475.
PMID: 21459331
Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected individuals. Nonetheless, blockade of the renin-angiotensin system...
17.
Allen I, Pace A, Jania L, Ledford J, Latour A, Snouwaert J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2006 Jul;
291(5):L1005-17.
PMID: 16829631
A genetic contribution to asthma susceptibility is well recognized, and linkage studies have identified a large number of genes associated with asthma pathogenesis. Recently, a locus encoding a seven-transmembrane protein...
18.
Miyamoto S, Snouwaert J, Koller B, Moy S, Lieberman J, Duncan G
Neuropsychopharmacology
. 2004 Oct;
29(12):2180-8.
PMID: 15467708
A mouse strain has been developed that expresses low levels of the NR1 subunit of the NMDA receptor. These mice are a model of chronic developmental NMDA receptor hypofunction and...
19.
Duncan G, Moy S, Perez A, Eddy D, Zinzow W, Lieberman J, et al.
Behav Brain Res
. 2004 Jul;
153(2):507-19.
PMID: 15265649
Reduced NMDA receptor function is hypothesized to contribute to the pathophysiology of schizophrenia. In order to model chronic and developmental NMDA receptor hypofunction, a mouse line was developed that expresses...
20.
Tam S, Tsai M, Snouwaert J, Kalesnikoff J, Scherrer D, Nakae S, et al.
Nat Immunol
. 2004 Jul;
5(8):844-52.
PMID: 15235600
Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that...