John N Falcone
Overview
Explore the profile of John N Falcone including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
261
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0
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Recent Articles
1.
Taylor S, Falcone J, Cantley L, Goncalves M
Nat Rev Cancer
. 2022 May;
22(8):452-466.
PMID: 35614234
Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic alterations and degree of interaction with systemic hormones and metabolites. These adaptations support the increased nutrient demand...
2.
Blow T, Hyde P, Falcone J, Neinstein A, Vasan N, Chitkara R, et al.
Integr Cancer Ther
. 2021 Jul;
20:15347354211032283.
PMID: 34259084
Alpelisib is a α-selective phosphatidylinositol 3-kinase (PI3K) inhibitor approved for treatment of postmenopausal women, and men, with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), PIK3CA-mutated,...
3.
Ferrer C, Lynch T, Sodi V, Falcone J, Schwab L, Peacock D, et al.
Mol Cell
. 2014 May;
54(5):820-31.
PMID: 24857547
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-GlcNAcase (OGA) levels. Reducing...