John M Wozney
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Explore the profile of John M Wozney including associated specialties, affiliations and a list of published articles.
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48
Citations
1414
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Recent Articles
1.
Seeherman H, Wilson C, Vanderploeg E, Brown C, Morales P, Fredricks D, et al.
J Bone Joint Surg Am
. 2021 May;
103(16):e64.
PMID: 33950879
Background: Supraphysiologic bone morphogenetic protein (BMP)-2 concentrations are required to induce spinal fusion. In this study, a BMP-2/BMP-6/activin A chimera (BV-265), optimized for BMP receptor binding, delivered in a recombinant...
2.
Seeherman H, Li X, Wozney J
J Bone Joint Surg Am
. 2020 Dec;
103(3):e8.
PMID: 33315697
Background: Synovial membrane-derived factors are implicated in arthritis-related bone changes. The route that synovial factors use to access subchondral bone and the mechanisms responsible for these bone changes remain unclear....
3.
Seeherman H, Berasi S, Brown C, Martinez R, Juo Z, Jelinsky S, et al.
Sci Transl Med
. 2019 Apr;
11(489).
PMID: 31019025
Bone morphogenetic protein (BMP)/carriers approved for orthopedic procedures achieve efficacy superior or equivalent to autograft bone. However, required supraphysiological BMP concentrations have been associated with potential local and systemic adverse...
4.
Wikesjo U, Lim W, Thomson R, Cook A, Wozney J, Hardwick W
J Periodontol
. 2018 Mar;
74(5):635-647.
PMID: 29539121
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) technologies have been shown to significantly support alveolar bone formation. Biomaterial limitations, however, have restricted the biologic potential for onlay indications. The objective...
5.
Seeherman H, Li X, Smith E, Parkington J, Li R, Wozney J
J Bone Joint Surg Am
. 2013 Jan;
95(1):36-47.
PMID: 23283371
Background: Osteoporosis results in a decrease in bone density, bone quality, and strength throughout the skeleton. Despite systemic therapies, the morbidity and mortality that are associated with hip fractures remain...
6.
Seeherman H, Li X, Smith E, Wozney J
J Bone Joint Surg Am
. 2012 Oct;
94(19):1765-76.
PMID: 23032587
Background: Transient bone resorption limits the use of recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponge in metaphyseal bone. The purpose of the present study was to evaluate the efficacy...
7.
Decker J, Lee J, Cortella C, Polimeni G, Rohrer M, Wozney J, et al.
J Periodontol
. 2010 Jul;
81(12):1839-49.
PMID: 20629551
Background: Endosseous implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a laboratory bench setting and air-dried induce relevant bone formation but also resident bone remodeling. Thus, the objective...
8.
Lee J, Decker J, Polimeni G, Cortella C, Rohrer M, Wozney J, et al.
J Clin Periodontol
. 2010 Mar;
37(6):582-90.
PMID: 20345393
Background: Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives: To compare the effect of implants fully or partially coated...
9.
Seeherman H, Li X, Bouxsein M, Wozney J
J Bone Joint Surg Am
. 2010 Feb;
92(2):411-26.
PMID: 20124069
Background: Bone resorption preceding bone formation has been reported following the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in an absorbable collagen sponge (ACS) in metaphyseal bone. This...
10.
Wikesjo U, Qahash M, Polimeni G, Susin C, Shanaman R, Rohrer M, et al.
J Clin Periodontol
. 2008 Nov;
35(11):1001-10.
PMID: 18976397
Background: Studies using ectopic rodent, orthotopic canine, and non-human primate models show that bone morphogenetic proteins (BMPs) coated onto titanium surfaces induce local bone formation. The objective of this study...