John M Pascal
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Explore the profile of John M Pascal including associated specialties, affiliations and a list of published articles.
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81
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3909
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Recent Articles
11.
Laspata N, Kaur P, Mersaoui S, Muoio D, Liu Z, Bannister M, et al.
Nucleic Acids Res
. 2023 Feb;
51(5):2215-2237.
PMID: 36794853
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a...
12.
Arnold M, Langelier M, Gartrell J, Kirby I, Sanderson D, Bejan D, et al.
Cell Chem Biol
. 2022 Dec;
29(12):1694-1708.e10.
PMID: 36493759
Allosteric coupling between the DNA binding site to the NAD-binding pocket drives PARP-1 activation. This allosteric communication occurs in the reverse direction such that NAD mimetics can enhance PARP-1's affinity...
13.
Kuttiyatveetil J, Soufari H, Dasovich M, Uribe I, Mirhasan M, Cheng S, et al.
Cell Rep
. 2022 Oct;
41(4):111529.
PMID: 36288691
PARP13/ZAP (zinc-finger antiviral protein) acts against multiple viruses by promoting degradation of viral mRNA. PARP13 has four N-terminal zinc (Zn) fingers that bind CG-rich nucleotide sequences, a C-terminal ADP ribosyltransferase...
14.
Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne M, Cyr N, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232396
The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize DNA, propagate DNA methylation and other epigenetic marks, perform quality control, repair nascent DNA, and...
15.
Xue H, Bhardwaj A, Yin Y, Fijen C, Ephstein A, Zhang L, et al.
Sci Adv
. 2022 Sep;
8(36):eabq0414.
PMID: 36070389
PARP inhibitors (PARPi) have emerged as promising cancer therapeutics capable of targeting specific DNA repair pathways, but their mechanism of action with respect to PARP1-DNA retention remains unclear. Here, we...
16.
Kotova E, Hsieh F, Chang H, Maluchenko N, Langelier M, Pascal J, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806109
Human poly(ADP)-ribose polymerase-1 (PARP1) is a global regulator of various cellular processes, from DNA repair to gene expression. The underlying mechanism of PARP1 action during transcription remains unclear. Herein, we...
17.
Rouleau-Turcotte E, Krastev D, Pettitt S, Lord C, Pascal J
Mol Cell
. 2022 Jul;
82(16):2939-2951.e5.
PMID: 35793673
PARP1 rapidly detects DNA strand break damage and allosterically signals break detection to the PARP1 catalytic domain to activate poly(ADP-ribose) production from NAD. PARP1 activation is characterized by dynamic changes...
18.
Rashid I, Tsai M, Sverzhinsky A, Hlaing A, Shih B, Thwin A, et al.
Methods Mol Biol
. 2022 Mar;
2444:243-269.
PMID: 35290642
With improvements in biophysical approaches, there is growing interest in characterizing large, flexible multi-protein complexes. The use of recombinant baculoviruses to express heterologous genes in cultured insect cells has advantages...
19.
Sverzhinsky A, Tomkinson A, Pascal J
Structure
. 2021 Nov;
30(3):371-385.e5.
PMID: 34838188
DNA ligases act in the final step of many DNA repair pathways and are commonly regulated by the DNA sliding clamp proliferating cell nuclear antigen (PCNA), but there are limited...
20.
Maluchenko N, Nilov D, Pushkarev S, Kotova E, Gerasimova N, Kirpichnikov M, et al.
Int J Mol Sci
. 2021 Nov;
22(22).
PMID: 34830005
Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme involved in DNA repair, chromatin organization and transcription. During transcription initiation, PARP1 interacts with gene promoters where it binds to nucleosomes, replaces linker...