John M Basgen
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Explore the profile of John M Basgen including associated specialties, affiliations and a list of published articles.
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475
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Recent Articles
1.
Reghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, et al.
Physiol Rep
. 2023 Jul;
11(13):e15688.
PMID: 37423891
Morphometric estimates of mean or individual glomerular volume (MGV, IGV) have biological implications, over and above qualitative histologic data. However, morphometry is time-consuming and requires expertise limiting its utility in...
2.
Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, et al.
JCI Insight
. 2023 Feb;
8(7).
PMID: 36853804
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking. We previously reported that kidney and brain...
3.
Basgen J, Wong J, Ray J, Nicholas S, Campbell K
Front Med (Lausanne)
. 2021 Sep;
8:745319.
PMID: 34568396
Podocyte foot process effacement is a key histologic finding in proteinuric kidney disease. We previously showed that 3-week old CD2AP-deficient mice have significant proteinuria, glomerular hypertrophy and mesangial expansion. The...
4.
Banu K, Lin Q, Basgen J, Planoutene M, Wei C, Reghuvaran A, et al.
JCI Insight
. 2021 Sep;
6(19).
PMID: 34473647
Herein, we report that Shroom3 knockdown, via Fyn inhibition, induced albuminuria with foot process effacement (FPE) without focal segmental glomerulosclerosis (FSGS) or podocytopenia. Interestingly, knockdown mice had reduced podocyte volumes....
5.
Cao A, Li J, Asadi M, Basgen J, Zhu B, Yi Z, et al.
J Clin Invest
. 2021 May;
131(10).
PMID: 33998601
Dachshund homolog 1 (DACH1), a key cell-fate determinant, regulates transcription by DNA sequence-specific binding. We identified diminished Dach1 expression in a large-scale screen for mutations that convert injury-resistant podocytes into...
6.
Takeda A, Murayama K, Okazaki Y, Imai-Okazaki A, Ohtake A, Takakuwa E, et al.
J Clin Pathol
. 2020 Aug;
PMID: 32817174
Aims: Mitochondrial cardiomyopathy (MCM) is difficult to make a definite diagnosis because of various cardiovascular phenotypes and no diagnostic criteria in the pathology examination. We aim to add myocardial pathology...
7.
Wei C, Banu K, Garzon F, Basgen J, Philippe N, Yi Z, et al.
J Am Soc Nephrol
. 2018 Oct;
29(11):2641-2657.
PMID: 30341149
Background: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin-binding protein important for epithelial morphogenesis,...
8.
Zhou Y, Castonguay P, Sidhom E, Clark A, Dvela-Levitt M, Kim S, et al.
Science
. 2017 Dec;
358(6368):1332-1336.
PMID: 29217578
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical...
9.
Singh R, Parveen M, Basgen J, Fazel S, Meshesha M, Thames E, et al.
Mol Cancer Res
. 2015 Oct;
14(1):78-92.
PMID: 26464213
Unlabelled: The initiation and progression of breast cancer is a complex process that is influenced by heterogeneous cell populations within the tumor microenvironment. Although adipocytes have been shown to promote...
10.
Weins A, Wong J, Basgen J, Gupta R, Daehn I, Casagrande L, et al.
Am J Pathol
. 2015 Jun;
185(8):2143-57.
PMID: 26073036
Podocyte loss is central to the progression of proteinuric kidney diseases leading to end-stage kidney disease (ESKD), requiring renal replacement therapy, such as dialysis. Despite modern tools and techniques, the...