John Lofblom
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Explore the profile of John Lofblom including associated specialties, affiliations and a list of published articles.
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102
Citations
1327
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Recent Articles
1.
Cheung P, Persson J, Zhang B, Vasylovska S, Lau J, Invast S, et al.
Sci Rep
. 2025 Jan;
15(1):417.
PMID: 39747317
A distinctive feature of both type 1 and type 2 diabetes is the waning of insulin-secreting beta cells in the pancreas. New methods for direct and specific targeting of the...
2.
Lechi F, Eriksson J, Odell L, Wegrzyniak O, Lofblom J, Frejd F, et al.
EJNMMI Radiopharm Chem
. 2024 Oct;
9(1):73.
PMID: 39460878
Background: In recent years, the interest in Al[F]F as a labeling agent for Positron Emission Tomography (PET) radiotracers has risen, as it allows for fast and efficient fluorine-18 labeling by...
3.
Zhang J, Rinne S, Yin W, Leitao C, Bjorklund E, Abouzayed A, et al.
ACS Pharmacol Transl Sci
. 2024 Oct;
7(10):3228-3240.
PMID: 39416966
The outcome of clinical trials evaluating drugs targeting the human epidermal growth factor receptor 3 (HER3) has been poor, with primary concerns related to lack of efficacy. HER3 is considered...
4.
Leitao C, Stahl S, Lofblom J
Microb Biotechnol
. 2024 Oct;
17(10):e70033.
PMID: 39403960
Bacterial surface display in combination with fluorescence-activated cell sorting is a versatile and robust system and an interesting alternative approach to phage display for the generation of therapeutic affinity proteins....
5.
Jonsson M, Mushtaq A, Nagy T, von Witting E, Lofblom J, Nam K, et al.
J Biol Chem
. 2024 Sep;
300(11):107795.
PMID: 39305954
Designing proteins with tunable activities from easily accessible external cues remains a biotechnological challenge. Here, we set out to create a small antibody-binding domain equipped with a molecular switch inspired...
6.
Ek M, Nilvebrant J, Nygren P, Stahl S, Lindberg H, Lofblom J
Front Immunol
. 2024 Aug;
15:1437886.
PMID: 39185427
Heterozygous loss-of-function mutations in the gene are a common cause of frontotemporal dementia. Such mutations lead to decreased plasma and cerebrospinal fluid levels of progranulin (PGRN), a neurotrophic factor with...
7.
Wegrzyniak O, Lechi F, Mitran B, Cheung P, Bitzios A, Persson J, et al.
iScience
. 2024 Apr;
27(5):109688.
PMID: 38660405
Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an...
8.
Parks L, Ek M, Stahl S, Lofblom J
Biochem Biophys Res Commun
. 2024 Jan;
696:149534.
PMID: 38241810
Autotransporters constitute a large family of natural proteins that are essential for delivering many types of proteins and peptides across the outer membrane in Gram-negative bacteria. In biotechnology, autotransporters have...
9.
Cheung P, Thorngren J, Zhang B, Vasylovska S, Lechi F, Persson J, et al.
EJNMMI Res
. 2023 Dec;
13(1):107.
PMID: 38100042
Background: Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages...
10.
Puuvuori E, Shen Y, Hulsart-Billstrom G, Mitran B, Zhang B, Cheung P, et al.
J Nucl Med
. 2023 Dec;
65(2):294-299.
PMID: 38050119
Rheumatoid arthritis (RA) is the most common inflammatory joint disease, and early diagnosis is key for effective disease management. CD69 is one of the earliest cell surface markers seen at...