John L Magnani
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Explore the profile of John L Magnani including associated specialties, affiliations and a list of published articles.
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34
Citations
1316
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Recent Articles
11.
Devata S, Angelini D, Blackburn S, Hawley A, Myers D, Schaefer J, et al.
Res Pract Thromb Haemost
. 2020 Feb;
4(2):193-204.
PMID: 32110749
Background: There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune...
12.
Muz B, Azab F, Fiala M, King J, Kohnen D, Fogler W, et al.
Blood Cancer J
. 2019 Aug;
9(9):68.
PMID: 31431613
No abstract available.
13.
Esposito M, Mondal N, Greco T, Wei Y, Spadazzi C, Lin S, et al.
Nat Cell Biol
. 2019 Apr;
21(5):627-639.
PMID: 30988423
How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated...
14.
Magnani J
Methods Mol Biol
. 2018 Jun;
1804:419-427.
PMID: 29926422
Determination of a glycolipid ligand can quickly reveal the carbohydrate epitope recognized by carbohydrate-binding proteins (CBP) which may include antibodies, lectins, toxins, and virulence factors. Thin layer chromatography (TLC) is...
15.
Laird C, Hassanein W, ONeill N, French B, Cheng X, Fogler W, et al.
Xenotransplantation
. 2018 Jan;
25(2):e12381.
PMID: 29359469
Background: Alongside the need to develop more effective and less toxic immunosuppression, the shortage of human organs available for organ transplantation is one of the major hurdles facing the field....
16.
Morikis V, Chase S, Wun T, Chaikof E, Magnani J, Simon S
Blood
. 2017 Aug;
130(19):2101-2110.
PMID: 28811304
E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands...
17.
Culmer D, Dunbar M, Hawley A, Sood S, Sigler R, Henke P, et al.
Thromb Haemost
. 2017 Mar;
117(6):1171-1181.
PMID: 28300869
Selectins, such as E-selectin (CD62E), function in venous thrombosis by binding and activating immune cells to initiate the coagulation cascade. GMI-1271 is a small molecule antagonist that inhibits E-selectin activity....
18.
Dutta P, Hoyer F, Sun Y, Iwamoto Y, Tricot B, Weissleder R, et al.
Arterioscler Thromb Vasc Biol
. 2016 Jul;
36(9):1802-8.
PMID: 27470513
Objective: Atherosclerosis is a chronic disease characterized by lipid accumulation in the arterial wall. After myocardial infarction (MI), atherosclerotic plaques are infiltrated by inflammatory myeloid cells that aggravate the disease...
19.
Telen M, Wun T, McCavit T, De Castro L, Krishnamurti L, Lanzkron S, et al.
Blood
. 2015 Mar;
125(17):2656-64.
PMID: 25733584
Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids. Animal models support the effectiveness of the pan-selectin inhibitor GMI-1070 in...
20.
Wun T, Styles L, DeCastro L, Telen M, Kuypers F, Cheung A, et al.
PLoS One
. 2014 Jul;
9(7):e101301.
PMID: 24988449
Background: Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been...