John L Macomber
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Explore the profile of John L Macomber including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
217
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Recent Articles
1.
McConnell A, Zhang X, Macomber J, Chau B, Sheffer J, Rahmanian S, et al.
MAbs
. 2014 Dec;
6(5):1274-82.
PMID: 25517312
Antibody engineering to enhance thermostability may enable further application and ease of use of antibodies across a number of different areas. A modified human IgG framework has been developed through...
2.
Bowers P, Horlick R, Kehry M, Neben T, Tomlinson G, Altobell L, et al.
Methods
. 2013 Jun;
65(1):44-56.
PMID: 23792919
Recent advances are described for the isolation and affinity maturation of antibodies that couple in vitro somatic hypermutation (SHM) with mammalian cell display, replicating key aspects of the adaptive immune...
3.
Horlick R, Macomber J, Bowers P, Neben T, Tomlinson G, Krapf I, et al.
J Biol Chem
. 2013 May;
288(27):19861-9.
PMID: 23689374
A mammalian expression system has been developed that permits simultaneous cell surface display and secretion of the same protein through alternate splicing of pre-mRNA. This enables a flexible system for...
4.
Bowers P, Neben T, Tomlinson G, Dalton J, Altobell L, Zhang X, et al.
J Biol Chem
. 2013 Jan;
288(11):7688-7696.
PMID: 23355464
A method for simultaneous humanization and affinity maturation of monoclonal antibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in vitro. To minimize...
5.
McConnell A, Spasojevich V, Macomber J, Krapf I, Chen A, Sheffer J, et al.
Protein Eng Des Sel
. 2012 Nov;
26(2):151-64.
PMID: 23173178
Antibodies are important tools for a broad range of applications due to their high specificity and ability to recognize virtually any target molecule. However, in order to be practically useful,...
6.
McConnell A, Do M, Neben T, Spasojevic V, MacLaren J, Chen A, et al.
PLoS One
. 2012 Nov;
7(11):e49458.
PMID: 23166676
A method has been developed for the rapid generation of high-affinity humanized antibodies from immunized animals without the need to make conventional hybridomas. Rearranged IgH D(J) regions were amplified from...
7.
Bowers P, Horlick R, Neben T, Toobian R, Tomlinson G, Dalton J, et al.
Proc Natl Acad Sci U S A
. 2011 Dec;
108(51):20455-60.
PMID: 22158898
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM)...
8.
Palackal N, Lyon C, Zaidi S, Luginbuhl P, Dupree P, Goubet F, et al.
Appl Microbiol Biotechnol
. 2006 Nov;
74(1):113-24.
PMID: 17103163
A unique multifunctional glycosyl hydrolase was discovered by screening an environmental DNA library prepared from a microbial consortium collected from cow rumen. The protein consists of two adjacent catalytic domains....