John J Masters
Overview
Explore the profile of John J Masters including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
19
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Recent Articles
1.
Zanotti-Fregonara P, Barth V, Liow J, Zoghbi S, Clark D, Rhoads E, et al.
Eur J Nucl Med Mol Imaging
. 2012 Nov;
40(2):245-53.
PMID: 23135321
Purpose: Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1 and mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1. Methods: LY2428703, a full mGluR1 antagonist...
2.
Franciskovich J, Masters J, Weber W, Klimkowski V, Chouinard M, Sipes P, et al.
Bioorg Med Chem Lett
. 2007 Nov;
17(24):6910-3.
PMID: 17976987
Several P4 domain derivatives of the general d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent...
3.
Mendel D, Marquart A, Joseph S, Waid P, Yee Y, Tebbe A, et al.
Bioorg Med Chem Lett
. 2007 Jul;
17(17):4832-6.
PMID: 17624775
SAR about the B-ring of a series of N(2)-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1' and S4 sites, respectively, afforded...
4.
Cases-Thomas M, Masters J, Walter M, Campbell G, Haughton L, Gallagher P, et al.
Bioorg Med Chem Lett
. 2006 Jan;
16(7):2022-5.
PMID: 16413778
A novel series of tertiary alcohol containing 2-substituted benzyl morpholines have been discovered as potent and selective inhibitors of the norepinephrine transporter. Efficient synthetic routes were developed featuring a highly...
5.
Franciskovich J, Masters J, Tinsley J, Craft T, Froelich L, Gifford-Moore D, et al.
Bioorg Med Chem Lett
. 2005 Sep;
15(21):4838-41.
PMID: 16140530
Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A...
6.
Beadle C, Boot J, Camp N, Dezutter N, Findlay J, Hayhurst L, et al.
Bioorg Med Chem Lett
. 2005 Sep;
15(20):4432-7.
PMID: 16137883
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final...
7.
Sheehan S, Masters J, Wiley M, Young S, Liebeschuetz J, Jones S, et al.
Bioorg Med Chem Lett
. 2003 Jun;
13(14):2255-9.
PMID: 12824013
A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor...