John H Wolfe
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Explore the profile of John H Wolfe including associated specialties, affiliations and a list of published articles.
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70
Citations
2174
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Recent Articles
1.
Choi E, Wolfe J, Kaler S
Hum Mol Genet
. 2025 Jan;
PMID: 39815619
The choroid plexuses (CP) are highly vascularized structures that project into the ventricles of the vertebrate brain. The polarized epithelia of the CP produce cerebrospinal fluid by transporting water and...
2.
Hunter J, Vite C, Molony C, ODonnell P, Wolfe J
Gene Ther
. 2024 Dec;
PMID: 39653737
Widespread distribution of transduced brain cells following delivery of AAV vectors into the cerebrospinal fluid (CSF) of the cisterna magna (CM) has been demonstrated in large animal brains. In humans,...
3.
Hunter J, Molony C, Bagel J, ODonnell P, Vite C, Chawla S, et al.
Mol Ther Methods Clin Dev
. 2024 Jul;
32(2):101272.
PMID: 38946937
Alpha-mannosidosis is caused by a genetic deficiency of lysosomal alpha-mannosidase, leading to the widespread presence of storage lesions in the brain and other tissues. Enzyme replacement therapy is available but...
4.
Hunter J, Molony C, Bagel J, ODonnell P, Kaler S, Wolfe J
Mol Ther Methods Clin Dev
. 2022 Aug;
26:384-393.
PMID: 36034772
Multiple studies have examined the transduction characteristics of different AAV serotypes in the mouse brain, where they can exhibit significantly different patterns of transduction. The pattern of transduction also varies...
5.
Ripolles-Garcia A, Dolgova N, Phillips M, Savina S, Ludwig A, Stuedemann S, et al.
Stem Cell Reports
. 2022 Jul;
17(8):1824-1841.
PMID: 35905738
Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to...
6.
Siddiqi F, Trakimas A, Joseph D, Lippincott M, Marsh E, Wolfe J
Cereb Cortex
. 2021 Jul;
31(11):5206-5224.
PMID: 34228108
Cortical interneurons (GABAergic cells) arise during embryogenesis primarily from the medial and caudal ganglionic eminences (MGE and CGE, respectively) with a small population generated from the preoptic area (POA). Progenitors...
7.
Yoon S, Hunter J, Chawla S, Clarke D, Molony C, ODonnell P, et al.
Brain
. 2020 Jul;
143(7):2058-2072.
PMID: 32671406
Intravascular injection of certain adeno-associated virus vector serotypes can cross the blood-brain barrier to deliver a gene into the CNS. However, gene distribution has been much more limited within the...
8.
Jackson M, Wood N, Zhao S, Augst A, Wolfe J, Gedroyc W, et al.
Artery Res
. 2019 Mar;
3(1):32-38.
PMID: 30881518
Background: Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate...
9.
Hunter J, Gurda B, Yoon S, Castle M, Wolfe J
Methods Mol Biol
. 2019 Feb;
1950:107-122.
PMID: 30783970
Techniques to localize vector transgenes in cells and tissues are essential in order to fully characterize gene therapy outcomes. In situ hybridization (ISH) uses synthesized complementary RNA or DNA nucleotide...
10.
Cuoco J, Esposito A, Moriarty S, Tang Y, Seth S, Toia A, et al.
Cerebellum
. 2017 Oct;
17(2):173-190.
PMID: 29043563
C57BL/6 mice exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the posterior vermis, indicative of neuronal migration defect during cerebellar development. Recognizing that...