John H Carson
Overview
Explore the profile of John H Carson including associated specialties, affiliations and a list of published articles.
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23
Citations
713
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Recent Articles
1.
Falkenberg C, Carson J, Blinov M
Biophys J
. 2017 Mar;
113(2):235-245.
PMID: 28242011
RNA granules are ensembles of specific RNA and protein molecules that mediate localized translation in eukaryotic cells. The mechanisms for formation and selectivity of RNA granules are unknown. Here we...
2.
Rovozzo R, Korza G, Baker M, Li M, Bhattacharyya A, Barbarese E, et al.
PLoS One
. 2016 Dec;
11(12):e0168204.
PMID: 28005950
CGG repeats in the 5'UTR of Fragile X Mental Retardation 1 (FMR1) RNA mediate RNA localization and translation in granules. Large expansions of CGG repeats (> 200 repeats) in FMR1,...
3.
Barbarese E, Ifrim M, Hsieh L, Guo C, Tatavarty V, Maggipinto M, et al.
PLoS One
. 2013 Aug;
8(8):e69989.
PMID: 23936366
In neurons, specific RNAs are assembled into granules, which are translated in dendrites, however the functional consequences of granule assembly are not known. Tumor overexpressed gene (TOG) is a granule-associated...
4.
Giampetruzzi A, Carson J, Barbarese E
Mol Cell Neurosci
. 2013 Jul;
56:333-41.
PMID: 23891804
Fragile X syndrome (FXS) is caused by lack of expression of fragile X mental retardation protein (FMRP), the product of the Fmr1 gene. In many cases FXS is associated with...
5.
Tatavarty V, Ifrim M, Levin M, Korza G, Barbarese E, Yu J, et al.
Mol Biol Cell
. 2012 Jan;
23(5):918-29.
PMID: 22219377
Dendritic RNAs are localized and translated in RNA granules. Here we use single-molecule imaging to count the number of RNA molecules in each granule and to record translation output from...
6.
Chen Y, Bai P, Mackay S, Korza G, Carson J, Kuchta R, et al.
J Virol
. 2010 Nov;
85(2):968-78.
PMID: 21068246
The heterotrimeric helicase-primase complex of herpes simplex virus type I (HSV-1), consisting of UL5, UL8, and UL52, possesses 5' to 3' helicase, single-stranded DNA (ssDNA)-dependent ATPase, primase, and DNA binding...
7.
Francone V, Ifrim M, Rajagopal C, Leddy C, Wang Y, Carson J, et al.
Mol Endocrinol
. 2010 Jun;
24(8):1543-58.
PMID: 20573687
Neurons and endocrine cells package peptides in secretory granules (large dense-core vesicles) for storage and stimulated release. Studies of peptidylglycine alpha-amidating monooxygenase (PAM), an essential secretory granule membrane enzyme, revealed...
8.
Han S, Friend L, Carson J, Korza G, Barbarese E, Maggipinto M, et al.
Traffic
. 2010 Apr;
11(7):886-98.
PMID: 20406423
Trafficking of mRNA molecules from the nucleus to distal processes in neural cells is mediated by heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 trans-acting factors. Although hnRNP A2/B1 is alternatively spliced to...
9.
Levin M, Hingorani M, Holmes R, Patel S, Carson J
Methods Mol Biol
. 2009 Apr;
500:335-59.
PMID: 19399438
Regression analysis is indispensible for quantitative understanding of biological systems and for developing accurate computational models. By applying regression analysis, one can validate models and quantify components of the system,...
10.
Carson J, Gao Y, Tatavarty V, Levin M, Korza G, Francone V, et al.
Biochim Biophys Acta
. 2008 Apr;
1779(8):453-8.
PMID: 18442491
In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in...