Marius F Ifrim
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Explore the profile of Marius F Ifrim including associated specialties, affiliations and a list of published articles.
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10
Citations
300
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Recent Articles
1.
Wilkerson J, Ifrim M, Valdez-Sinon A, Hahn P, Bowles J, Molinaro G, et al.
Neurobiol Dis
. 2023 Apr;
182:106136.
PMID: 37120096
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in...
2.
Ifrim M, Janusz-Kaminska A, Bassell G
Cell Rep
. 2022 Nov;
41(7):111658.
PMID: 36384114
The ubiquitination/proteasome system is important for the spatiotemporal control of protein synthesis and degradation at synapses, while dysregulation may underlie autism spectrum disorders (ASDs). However, methods allowing direct visualization of...
3.
Rodriguez C, Wright S, Kearse M, Haenfler J, Flores B, Liu Y, et al.
Nat Neurosci
. 2020 Feb;
23(3):386-397.
PMID: 32066985
Repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN) from the FMR1 5'-leader produces toxic proteins that contribute to neurodegeneration in fragile X-associated tremor/ataxia syndrome. Here we describe how unexpanded...
4.
Banerjee A, Ifrim M, Valdez A, Raj N, Bassell G
Brain Res
. 2018 Apr;
1693(Pt A):24-36.
PMID: 29653083
Research in the past decades has unfolded the multifaceted role of Fragile X mental retardation protein (FMRP) and how its absence contributes to the pathophysiology of Fragile X syndrome (FXS)....
5.
Suhl J, Muddashetty R, Anderson B, Ifrim M, Visootsak J, Bassell G, et al.
Proc Natl Acad Sci U S A
. 2015 Nov;
112(47):E6553-61.
PMID: 26554012
Fragile X syndrome is a common cause of intellectual disability and autism spectrum disorder. The gene underlying the disorder, fragile X mental retardation 1 (FMR1), is silenced in most cases...
6.
Ifrim M, Williams K, Bassell G
J Neurosci
. 2015 May;
35(18):7116-30.
PMID: 25948262
Fragile X syndrome (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP), an RNA binding protein that regulates translation of numerous target mRNAs, some of...
7.
Barbarese E, Ifrim M, Hsieh L, Guo C, Tatavarty V, Maggipinto M, et al.
PLoS One
. 2013 Aug;
8(8):e69989.
PMID: 23936366
In neurons, specific RNAs are assembled into granules, which are translated in dendrites, however the functional consequences of granule assembly are not known. Tumor overexpressed gene (TOG) is a granule-associated...
8.
Tatavarty V, Ifrim M, Levin M, Korza G, Barbarese E, Yu J, et al.
Mol Biol Cell
. 2012 Jan;
23(5):918-29.
PMID: 22219377
Dendritic RNAs are localized and translated in RNA granules. Here we use single-molecule imaging to count the number of RNA molecules in each granule and to record translation output from...
9.
Francone V, Ifrim M, Rajagopal C, Leddy C, Wang Y, Carson J, et al.
Mol Endocrinol
. 2010 Jun;
24(8):1543-58.
PMID: 20573687
Neurons and endocrine cells package peptides in secretory granules (large dense-core vesicles) for storage and stimulated release. Studies of peptidylglycine alpha-amidating monooxygenase (PAM), an essential secretory granule membrane enzyme, revealed...
10.
Livingston C, Ifrim M, Cowan A, Weller S
PLoS Pathog
. 2009 Oct;
5(10):e1000619.
PMID: 19816571
Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication compartments (RC) during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of...