John E Cochran
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Explore the profile of John E Cochran including associated specialties, affiliations and a list of published articles.
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7
Citations
70
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Recent Articles
1.
ODowd H, Manske J, Freedman S, Cochran J
Org Lett
. 2022 Apr;
24(18):3431-3434.
PMID: 35486487
The desymmetrization of a prochiral 6-oxaspiro[3.3]heptane-2-carboxylic acid derivative via biocatalytic ketoreductase-mediated reduction has provided access to both enantiomers in high ee. The axially chiral alcohol was converted to the corresponding...
2.
Boyd M, Collier P, Clark M, Deng H, Kesavan S, Ronkin S, et al.
J Med Chem
. 2021 Dec;
64(24):17777-17794.
PMID: 34871500
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen for inhibitors of elongation of very long chain fatty...
3.
Capani Jr J, Cochran J, Liang J
J Org Chem
. 2019 Jun;
84(14):9378-9384.
PMID: 31194913
A practical and mild set of conditions for the Sonogashira reaction utilizing CsF-mediated in situ TMS-alkyne desilylation followed by Sonogashira coupling has been developed for the synthesis of a variety...
4.
Farmer L, Ledeboer M, Hoock T, Arnost M, Bethiel R, Bennani Y, et al.
J Med Chem
. 2015 Aug;
58(18):7195-216.
PMID: 26230873
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential...
5.
Duffy J, Harrington E, Salituro F, Cochran J, Green J, Gao H, et al.
ACS Med Chem Lett
. 2014 Jun;
2(10):758-63.
PMID: 24900264
The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to the identification...
6.
Padwa A, Kappe C, Cochran J, Snyder J
J Org Chem
. 1997 May;
62(9):2786-2797.
PMID: 11671641
The alpha-thiocarbocation generated from the Pummerer reaction of an o-amido-substituted sulfoxide is intercepted by the adjacent amido carbonyl group to produce a 2-amino-substituted isobenzofuran as a transient intermediate. In the...
7.
Padwa A, Cochran J, Kappe C
J Org Chem
. 1996 May;
61(11):3706-3714.
PMID: 11667219
The alpha-thiocarbocation generated from the Pummerer reaction of an o-benzoyl-substituted sulfoxide is intercepted by the adjacent keto group to produce an alpha-thio isobenzofuran as a transient intermediate which undergoes a...