John Chu
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Explore the profile of John Chu including associated specialties, affiliations and a list of published articles.
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34
Citations
900
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Recent Articles
1.
Chiou S, Chang C, Chu J
ChemMedChem
. 2025 Jan;
:e202400498.
PMID: 39822069
Cofactors are non-protein entities necessary for proteins to operate. They provide "functional groups" beyond those of the 20 canonical amino acids and enable proteins to carry out more diverse functions....
2.
Ma T, Chu J
Beilstein J Org Chem
. 2024 Nov;
20:3050-3060.
PMID: 39600953
Bioactivity-guided fractionation (BGF) has historically been a fruitful natural product discovery workflow. However, it is plagued by increasing rediscovery rates in recent years and new methods capable of exploring the...
3.
Tan H, Liu W, Ho J, Chen Y, Shieh F, Liao H, et al.
ACS Chem Biol
. 2024 Aug;
19(9):1982-1990.
PMID: 39163642
Microcin J25 (MccJ25), a lasso peptide antibiotic with a unique structure that resembles the lariat knot, has been a topic of intense interest since its discovery in 1992. The precursor...
4.
Chiou S, Chen Y, Lee C, Ho M, Miao J, Kuo P, et al.
Angew Chem Int Ed Engl
. 2023 Dec;
63(5):e202317522.
PMID: 38085688
The prevalence of drug-resistant bacterial pathogens foreshadows a healthcare crisis. Calcium-dependent antibiotics (CDAs) are promising candidates to combat infectious diseases as many of them show modes of action (MOA) orthogonal...
5.
Jian B, Chiou S, Hsu C, Ho J, Wu Y, Chu J
ACS Chem Biol
. 2023 Feb;
18(3):476-483.
PMID: 36820820
The traditional natural product discovery approach has accessed only a fraction of the chemical diversity in nature. The use of bioinformatic tools to interpret the instructions encoded in microbial biosynthetic...
6.
Chen I, Cheng T, Wang Y, Huang S, Hsiao Y, Lai Y, et al.
Chembiochem
. 2022 Oct;
23(24):e202200563.
PMID: 36278314
Capreomycidine (Cap) is a nonproteinogenic amino acid and building block of nonribosomal peptide (NRP) natural products. We report the formation and activation of Cap in capreomycin biosynthesis. CmnC and CmnD...
7.
Chen P, Sung L, Hegemann J, Chu J
ChemMedChem
. 2022 Feb;
17(10):e202200075.
PMID: 35201676
The use of synergistic antibiotic combinations has emerged as a viable approach to contain the rapid spread of antibiotic-resistant pathogens. Here we report the discovery of a new strongly synergistic...
8.
Wu C, Chu J
Front Chem
. 2021 Oct;
9:741290.
PMID: 34595153
Natural products are often the starting point for drug development and also the testing ground for synthetic methods. Herein we describe the total synthesis and antimicrobial evaluation of a marine...
9.
Chung H, Kao C, Wang T, Chu J, Pei J, Hsu C
Anal Chem
. 2021 Jan;
93(4):2456-2463.
PMID: 33416326
Combinatorial synthesis has been widely used as an efficient strategy to screen for active compounds. Mass spectrometry is the method of choice in the identification of hits resulting from high-throughput...
10.
Chu J, Koirala B, Forelli N, Vila-Farres X, Ternei M, Ali T, et al.
J Am Chem Soc
. 2020 Jul;
142(33):14158-14168.
PMID: 32697091
Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent, new antibiotic lead structures and activities are desperately...