Melinda A Ternei
Overview
Explore the profile of Melinda A Ternei including associated specialties, affiliations and a list of published articles.
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23
Citations
877
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Recent Articles
1.
Kan J, Morales A, Hernandez Y, Ternei M, Lemetre C, Maclntyre L, et al.
bioRxiv
. 2024 Jun;
PMID: 38854004
Gonorrhea, which is caused by , is the second most reported sexually transmitted infection worldwide. The increasing appearance of isolates that are resistant to approved therapeutics raises the concern that...
2.
Burian J, Libis V, Hernandez Y, Guerrero-Porras L, Ternei M, Brady S
Nat Biotechnol
. 2022 Nov;
41(5):626-630.
PMID: 36411313
The capture of metagenomic DNA in large clone libraries provides the opportunity to study microbial diversity that is inaccessible using culture-dependent methods. In this study, we harnessed nuclease-deficient Cas9 to...
3.
Libis V, MacIntyre L, Mehmood R, Guerrero L, Ternei M, Antonovsky N, et al.
Nat Commun
. 2022 Sep;
13(1):5256.
PMID: 36068239
Bacterial genomes contain large reservoirs of biosynthetic gene clusters (BGCs) that are predicted to encode unexplored natural products. Heterologous expression of previously unstudied BGCs should facilitate the discovery of additional...
4.
Li L, Koirala B, Hernandez Y, MacIntyre L, Ternei M, Russo R, et al.
Nat Microbiol
. 2021 Dec;
7(1):120-131.
PMID: 34949828
The emergence of multidrug-resistant bacteria poses a threat to global health and necessitates the development of additional in vivo active antibiotics with diverse modes of action. Directly targeting menaquinone (MK),...
5.
Chu J, Koirala B, Forelli N, Vila-Farres X, Ternei M, Ali T, et al.
J Am Chem Soc
. 2020 Jul;
142(33):14158-14168.
PMID: 32697091
Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent, new antibiotic lead structures and activities are desperately...
6.
Libis V, Antonovsky N, Zhang M, Shang Z, Montiel D, Maniko J, et al.
Nat Commun
. 2019 Aug;
10(1):3848.
PMID: 31451725
Sequencing of DNA extracted from environmental samples can provide key insights into the biosynthetic potential of uncultured bacteria. However, the high complexity of soil metagenomes, which can contain thousands of...
7.
Wu C, Shang Z, Lemetre C, Ternei M, Brady S
J Am Chem Soc
. 2019 Feb;
141(9):3910-3919.
PMID: 30735616
The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are active against resistant pathogens. Calcium-dependent antibiotics are a small family of structurally diverse acidic lipopeptides assembled by...
8.
Kim S, Lu W, Ahmadi M, Montiel D, Ternei M, Brady S
ACS Synth Biol
. 2018 Dec;
8(1):109-118.
PMID: 30575381
Most natural product biosynthetic gene clusters identified in bacterial genomic and metagenomic sequencing efforts are silent under laboratory growth conditions. Here, we describe a scalable biosynthetic gene cluster activation method...
9.
Peek J, Lilic M, Montiel D, Milshteyn A, Woodworth I, Biggins J, et al.
Nat Commun
. 2018 Oct;
9(1):4147.
PMID: 30297823
Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these compounds is threatened by the increasing incidence of resistance...
10.
Hover B, Kim S, Katz M, Charlop-Powers Z, Owen J, Ternei M, et al.
Nat Microbiol
. 2018 Feb;
3(4):415-422.
PMID: 29434326
Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide . In the absence of new therapies, mortality rates due to untreatable infections are predicted...