John C Whittaker
Overview
Explore the profile of John C Whittaker including associated specialties, affiliations and a list of published articles.
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Articles
76
Citations
5331
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Recent Articles
1.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2024 Apr;
56(5):1032-1033.
PMID: 38641645
No abstract available.
2.
Burgess S, Mason A, Grant A, Slob E, Gkatzionis A, Zuber V, et al.
Am J Hum Genet
. 2023 Feb;
110(2):195-214.
PMID: 36736292
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive and slow to obtain. In contrast, evidence from conventional observational epidemiological studies is less reliable...
3.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2019 May;
51(6):1067.
PMID: 31110354
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Wadsworth C, Dixon P, Taylor-Robinson S, Kim J, Zabron A, Wong J, et al.
J Clin Exp Hepatol
. 2019 Apr;
9(2):171-175.
PMID: 31024198
Background And Aims: Understanding of the significant genetic risk factors for Cholangiocarcinoma (CC) remains limited. Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase...
5.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2019 Feb;
51(3):481-493.
PMID: 30804560
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define...
6.
Swerdlow D, Kuchenbaecker K, Shah S, Sofat R, Holmes M, White J, et al.
Int J Epidemiol
. 2016 Jun;
45(5):1600-1616.
PMID: 27342221
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that instrument these exposures. The approach is gaining popularity-our systematic review reveals...
7.
White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, et al.
Lancet Diabetes Endocrinol
. 2016 Jan;
4(4):327-36.
PMID: 26781229
Background: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart...
8.
Nelson M, Tipney H, Painter J, Shen J, Nicoletti P, Shen Y, et al.
Nat Genet
. 2015 Jun;
47(8):856-60.
PMID: 26121088
Over a quarter of drugs that enter clinical development fail because they are ineffective. Growing insight into genes that influence human disease may affect how drug targets and indications are...
9.
Moore G, Ishida M, Demetriou C, Al-Olabi L, Leon L, Thomas A, et al.
Philos Trans R Soc Lond B Biol Sci
. 2015 Jan;
370(1663):20140074.
PMID: 25602077
Identifying the genetic input for fetal growth will help to understand common, serious complications of pregnancy such as fetal growth restriction. Genomic imprinting is an epigenetic process that silences one...
10.
Talmud P, Cooper J, Morris R, Dudbridge F, Shah T, Engmann J, et al.
Diabetes
. 2014 Dec;
64(5):1830-40.
PMID: 25475436
We developed a 65 type 2 diabetes (T2D) variant-weighted gene score to examine the impact on T2D risk assessment in a U.K.-based consortium of prospective studies, with subjects initially free...