John C Whittaker
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Explore the profile of John C Whittaker including associated specialties, affiliations and a list of published articles.
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76
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5331
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Recent Articles
11.
Futema M, Shah S, Cooper J, Li K, Whittall R, Sharifi M, et al.
Clin Chem
. 2014 Nov;
61(1):231-8.
PMID: 25414277
Background: Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused by mutations in 1 of 3 genes. In the 60% of patients who are mutation negative, we have recently shown that...
12.
Swerdlow D, Preiss D, Kuchenbaecker K, Holmes M, Engmann J, Shah T, et al.
Lancet
. 2014 Sep;
385(9965):351-61.
PMID: 25262344
Background: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the...
13.
Silverwood R, Holmes M, Dale C, Lawlor D, Whittaker J, Davey Smith G, et al.
Int J Epidemiol
. 2014 Sep;
43(6):1781-90.
PMID: 25192829
Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome. In some cases, however, observational...
14.
Vimaleswaran K, Cavadino A, Berry D, Jorde R, Dieffenbach A, Lu C, et al.
Lancet Diabetes Endocrinol
. 2014 Jun;
2(9):719-29.
PMID: 24974252
Background: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation...
15.
Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, et al.
PLoS One
. 2013 Aug;
8(8):e71345.
PMID: 23977022
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have...
16.
Mann A, Mangtani P, Russell C, Whittaker J
BMJ Open
. 2013 Aug;
3(8).
PMID: 23906952
Objective: To investigate the impact on mortality due to pneumonia or influenza of the change from risk-based to age group-based targeting of the elderly for yearly influenza vaccination in England...
17.
Hu Y, Li L, Ehm M, Bing N, Song K, Nelson M, et al.
Am J Hum Genet
. 2013 Apr;
92(4):547-57.
PMID: 23541341
Clinical trials for preventative therapies are complex and costly endeavors focused on individuals likely to develop disease in a short time frame, randomizing them to treatment groups, and following them...
18.
Vimaleswaran K, Berry D, Lu C, Tikkanen E, Pilz S, Hiraki L, et al.
PLoS Med
. 2013 Feb;
10(2):e1001383.
PMID: 23393431
Background: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index...
19.
Chan K, Patel R, Newcombe P, Nelson C, Qasim A, Epstein S, et al.
J Am Coll Cardiol
. 2013 Jan;
61(9):957-70.
PMID: 23352782
Objectives: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD. Background:...
20.
Ehret G, Lamparter D, Hoggart C, Whittaker J, Beckmann J, Kutalik Z
Am J Hum Genet
. 2012 Nov;
91(5):863-71.
PMID: 23122585
There are many known examples of multiple semi-independent associations at individual loci; such associations might arise either because of true allelic heterogeneity or because of imperfect tagging of an unobserved...