John C Lawrence Jr
Overview
Explore the profile of John C Lawrence Jr including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1940
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Recent Articles
1.
Kim H, Kumar A, Wang L, Liu G, Keller S, Lawrence Jr J, et al.
Mol Cell Biol
. 2010 Apr;
30(12):3126-39.
PMID: 20385772
Lipin 1 is a bifunctional protein that regulates gene transcription and, as a Mg(2+)-dependent phosphatidic acid phosphatase (PAP), is a key enzyme in the biosynthesis of phospholipids and triacylglycerol. We...
2.
Kumar A, Lawrence Jr J, Jung D, Ko H, Keller S, Kim J, et al.
Diabetes
. 2010 Mar;
59(6):1397-406.
PMID: 20332342
Objective: Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin signaling intermediary that regulates glucose and...
3.
Wang L, Lawrence Jr J, Sturgill T, Harris T
J Biol Chem
. 2009 Apr;
284(22):14693-7.
PMID: 19346248
mTORC1 contains multiple proteins and plays a central role in cell growth and metabolism. Raptor (regulatory-associated protein of mammalian target of rapamycin (mTOR)), a constitutively binding protein of mTORC1, is...
4.
Chen Z, Gropler M, Norris J, Lawrence Jr J, Harris T, Finck B
Arterioscler Thromb Vasc Biol
. 2008 Aug;
28(10):1738-44.
PMID: 18669885
Objective: Lipin 1 controls fatty acid metabolism in the nucleus as a transcriptional regulator and in the cytosol as an enzyme catalyzing the penultimate step in phosphoglycerol triacylglyceride (TAG) synthesis....
5.
Wang L, Harris T, Lawrence Jr J
J Biol Chem
. 2008 Mar;
283(23):15619-27.
PMID: 18372248
The rapamycin-sensitive mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contains mTOR, raptor, mLST8, and PRAS40 (proline-rich Akt substrate of 40 kDa). PRAS40 functions as a negative regulator when bound...
6.
Kumar A, Harris T, Keller S, Choi K, Magnuson M, Lawrence Jr J
Mol Cell Biol
. 2007 Oct;
28(1):61-70.
PMID: 17967879
Rictor is an essential component of mTOR (mammalian target of rapamycin) complex 2 (mTORC2), a kinase complex that phosphorylates Akt at Ser473 upon activation of phosphatidylinositol 3-kinase (PI-3 kinase). Since...
7.
Wang L, Harris T, Roth R, Lawrence Jr J
J Biol Chem
. 2007 May;
282(27):20036-44.
PMID: 17510057
Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes, mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting of mTOR, raptor (regulatory-associated protein of mTOR), and...
8.
Kim Y, Gentry M, Harris T, Wiley S, Lawrence Jr J, Dixon J
Proc Natl Acad Sci U S A
. 2007 Apr;
104(16):6596-601.
PMID: 17420445
A newly emerging family of phosphatases that are members of the haloacid dehalogenase superfamily contains the catalytic motif DXDX(T/V). A member of this DXDX(T/V) phosphatase family known as Dullard was...
9.
Harris T, Huffman T, Chi A, Shabanowitz J, Hunt D, Kumar A, et al.
J Biol Chem
. 2006 Nov;
282(1):277-86.
PMID: 17105729
Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy (fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg(2+)-dependent phosphatidic acid phosphatase (PAP) activity than...
10.
Finck B, Gropler M, Chen Z, Leone T, Croce M, Harris T, et al.
Cell Metab
. 2006 Sep;
4(3):199-210.
PMID: 16950137
Perturbations in hepatic lipid homeostasis are linked to the development of obesity-related steatohepatitis. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of...